Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 11334
TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613968(US11739089, Compound 2)
Affinity DataIC50: 175nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 175nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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PDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583050(CHEMBL5094781 | US11739089, Compound 8)
Affinity DataIC50: 175nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583051(CHEMBL5080434 | US11739089, Compound 10)
Affinity DataIC50: 375nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613977(US11739089, Compound 11)
Affinity DataIC50: 375nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583060(CHEMBL5079066 | US11739089, Compound 23)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
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TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583053(CHEMBL5077462 | US11739089, Compound 7)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613969(US11739089, Compound 3)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613975(US11739089, Compound 9)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583068(CHEMBL5081940 | US11739089, Compound 17)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613970(US11739089, Compound 4)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583068(CHEMBL5081940 | US11739089, Compound 17)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583065(CHEMBL5072078 | US11739089, Compound 28)
Affinity DataIC50: 750nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50206310(ELACRIDAR HYDROCHLORIDE | N-4-[2-(1,2,3,4-Tetrahyd...)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583062(CHEMBL5074563 | US11739089, Compound 25)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583063(CHEMBL5075886 | US11739089, Compound 26)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583064(CHEMBL5076722 | US11739089, Compound 27)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583066(CHEMBL5090486 | US11739089, Compound 29)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583070(CHEMBL5074763 | US11739089, Compound 30)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583057(CHEMBL5077301 | US11739089, Compound 20)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50567579(Encequidar | Pgp inhibitor hm30181ak | HM-30181 | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583052(CHEMBL5084749 | US11739089, Compound 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583061(CHEMBL5081545 | US11739089, Compound 24)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583059(CHEMBL5073106 | US11739089, Compound 22)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583058(CHEMBL5094677 | US11739089, Compound 21)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583056(CHEMBL5074836 | US11739089, Compound 19)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583069(CHEMBL5076816 | US11739089, Compound 18)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583067(CHEMBL5083331 | US11739089, Compound 16)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613980(US11739089, Compound 15)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583067(CHEMBL5083331 | US11739089, Compound 16)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM50583054(CHEMBL5075114 | US11739089, Compound 6)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Athenex

US Patent
LigandPNGBDBM613971(US11739089, Compound 5)
Affinity DataIC50: 1.00E+3nMAssay Description:Test compounds, DMSO (negative control), and ketoconazole (positive control) were diluted to 4× final concentrations in water. The standard final Com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
Go to US Patent