Compile Data Set for Download or QSAR
Report error Found 315 Enz. Inhib. hit(s) with all data for entry = 11352
TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609060(US11702414, Example 2 | N-((1R,4r)-4-(5-(6-(3- cya...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609061(US11702414, Example 3 | N-((1r,4r)-4-(5-(6-(3- cya...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507689(7-(5-(5-(2-oxa-7- azaspiro[3.5]nonan-7-yl)- 1,3,4-...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507690(7-(5-(5-(hydroxymethyl)-1,3,4-thiadiazol-2-yl)-4-(...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507691(N-(1-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin-7-yl)-4...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507693(7-(5-(5-(4- acetylpiperazine-1- carbonyl)-1,3,4- t...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507694(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4- (i...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507695((S)-N-(1-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507696((R)-N-(1-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609070(US11702414, Example 14 | (R)-5-(6-(3- cyanopyrrolo...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507698(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4- (i...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507699((S)-7-(5-(5-(3-hydroxypyrrolidine-1-carbonyl)-1,3,...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507700((R)-7-(5-(5-(3- hydroxypyrrolidine-1- carbonyl)-1,...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507702(N-(5-(6-(3- cyanopyrrolo[1,2- b]pyridazin-7-yl)-4-...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609076(US11702414, Example 20 | N-((1r,4r)-4-(5-(4- ((cya...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609077(US11702414, Example 21 | N-((1r,4r)- 4-(5-(6-(3- c...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609078(US11702414, Example 22 | N-((1r,4r)- 4-(5-(6-(3- c...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609079(US11702414, Example 23 | methyl (((1R,3r)- 3-((5-(...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507707(N-((1r,4r)-4-(5-(6-(3-cyanopyrrolo[1,2-b]pyridazin...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507708(7-(4-(isopropylamino)-5-(5-methyl-1,3,4-thiadiazol...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507709(US11702414, Example 212 | 7-(5-(5-(2-aminoethyl)-1...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507710((R)-7-(5-(5-((2- fluoro-3-hydroxy-3- methylbutyl)a...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507713(7-(4-(isopropylamino)-5-(1,3,4-thiadiazol-2-yl)pyr...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507714(7-(5-(5-(3-hydroxy-3-methylbutyl)-1,3,4-thiadiazol...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507715(7-(4-(isopropylamino)-5-(5-(tetrahydro-2H-pyran-4-...)
Affinity DataIC50: 1nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507686(tert-butyl (2-(5-(6-(3- cyanopyrrolo[1,2- b]pyrida...)
Affinity DataIC50: 1.5nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507711(7-(5-(5-(1H-pyrrol-1- yl)-1,3,4-thiadiazol- 2-yl)-...)
Affinity DataIC50: 1.70nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507712(7-(4-(isopropylamino)-5-(5-(pyrrolidin-1-yl)-1,3,4...)
Affinity DataIC50: 1.80nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM507692(7-(5-(5-(4- aminophenyl)-1,3,4- thiadiazol-2-yl)-4...)
Affinity DataIC50: 9nMAssay Description:IRAK4 enzyme (Carna Biosciences, Chuo-ku, Kobe, Japan) activity was measured by detecting phosphorylated peptide substrate formation using an antibod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609313(US11702414, Example 278 | N-((1r,3r)-3-(5-(6-(3-cy...)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609276(US11702414, Example 239 | N-((1R,5S,6r)-3-(5-(6-(3...)
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609274(US11702414, Example 237 | 7-(5-(5-((1R,4R)-2-oxa-5...)
Affinity DataIC50: 140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609277(US11702414, Example 240 | N-((1R,5S,6s)-3-(5-(6-(3...)
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609327(US11702414, Example 292 | N-((1R,5S,8s)-3-(5-(6-(3...)
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609132(US11702414, Example 75 | 7-(5-(5-(7-acetyl-2,7-dia...)
Affinity DataIC50: 240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609324(US11702414, Example 289 | N-(((1s,3s)-3-(5-(6-(3-c...)
Affinity DataIC50: 240nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609164(US11702414, Example 125 | N-((1r,4r)-4-(5-(6-(3-cy...)
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609121(US11702414, Example 64 | N-((3S,4S)-1-(5-(6-(3-cya...)
Affinity DataIC50: 280nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609120(US11702414, Example 63 | N-((3S,4R)-1-(5-(6-(3-cya...)
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609289(US11702414, Example 252 | 7-(5-(5-(2-oxa-6-azaspir...)
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609122(US11702414, Example 65 | N-((3R,4R)-1-(5-(6-(3-cya...)
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609187(US11702414, Example 148 | N-((1R,5S,8S)-3-(5-(4-((...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609188(US11702414, Example 149 | 7-(5-(5-((1R,5S,8r)-8-hy...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609254(US11702414, Example 213 | 5-(6-(3-cyanopyrrolo[1,2...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609357(US11702414, Example 322 | 7-(4-(isopropylamino)-5-...)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609184(US11702414, Example 145 | 7-(5-(5-((1R,5S)-8-oxa-3...)
Affinity DataIC50: 330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609325(US11702414, Example 290 | N-(((1r,3r)-3-(5-(6-(3-c...)
Affinity DataIC50: 330nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609182(US11702414, Example 143 | methyl (((1R,3r)-3-((2-(...)
Affinity DataIC50: 340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609110(US11702414, Example 53 | N-((1R,5S,8S)-3-(5-(4-(((...)
Affinity DataIC50: 350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM609245(US11702414, Example 204 | 7-(5-(5-((3S,4S)-3-fluor...)
Affinity DataIC50: 350nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

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