Compile Data Set for Download or QSAR
Report error Found 104 Enz. Inhib. hit(s) with all data for entry = 11273
TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604253(US11661422, Example 1)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604253(US11661422, Example 1)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604254(US11661422, Example 2)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604254(US11661422, Example 2)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604258(US11661422, Example 3)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604258(US11661422, Example 3)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604269(US11661422, Example 5)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604269(US11661422, Example 5)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604287(US11661422, Example 7 | 4-(8-(4-((4-(methylsulfony...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604287(US11661422, Example 7 | 4-(8-(4-((4-(methylsulfony...)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604304(US11661422, Example 10)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604307(US11661422, Example 11)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604307(US11661422, Example 11)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604308(US11661422, Example 12 | 4-(9-(4-methoxyphenyl)-4-...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604308(US11661422, Example 12 | 4-(9-(4-methoxyphenyl)-4-...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604309(US11661422, Example 13)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604309(US11661422, Example 13)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604310(US11661422, Example 14)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604312(US11661422, Example 16)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604313(US11661422, Example 17 | 4-(2-(tert-Butyl)-4- meth...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604313(US11661422, Example 17 | 4-(2-(tert-Butyl)-4- meth...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604313(US11661422, Example 17 | 4-(2-(tert-Butyl)-4- meth...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604313(US11661422, Example 17 | 4-(2-(tert-Butyl)-4- meth...)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604314(US11661422, Example 18 | 9-(4-(4-Acetylpiperazin- ...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604314(US11661422, Example 18 | 9-(4-(4-Acetylpiperazin- ...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604314(US11661422, Example 18 | 9-(4-(4-Acetylpiperazin- ...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604314(US11661422, Example 18 | 9-(4-(4-Acetylpiperazin- ...)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: 100nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Incyte

US Patent
LigandPNGBDBM604315(US11661422, Example 19)
Affinity DataIC50: 100nMAssay Description:JAK2 enzyme activity assays utilize catalytic domain (JH1, amino acids 808-1132) of human JAK2 expressed as N-terminal His-tagged protein in a baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604316(US11661422, Example 20)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604316(US11661422, Example 20)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604317(US11661422, Example 21 | 4-(9-(4-(1- Aminocyclopro...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604317(US11661422, Example 21 | 4-(9-(4-(1- Aminocyclopro...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604318(US11661422, Example 22 | 4-(4-Methyl-9-(1- methyl-...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604318(US11661422, Example 22 | 4-(4-Methyl-9-(1- methyl-...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604319(US11661422, Example 23 | 4-(9-Cyclopropyl-4- methy...)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604321(US11661422, Example 25)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
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LigandPNGBDBM604321(US11661422, Example 25)
Affinity DataIC50: 100nMAssay Description:JAK2 JH2-V617F binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human V617F mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604253(US11661422, Example 1)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

LigandPNGBDBM604254(US11661422, Example 2)
Affinity DataIC50: 300nMAssay Description:JAK2 JH2-WT binding assay utilizes pseudo-kinase domain (JH2, amino-acids 536-812 with 3 surface mutations W659A, W777A, F794H) of human Wild Type JA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Incyte

US Patent
LigandPNGBDBM604262(US11661422, Example 4)
Affinity DataIC50: 300nMAssay Description:JAK2 JH1 binding assay utilizes catalytic domain (JH1, amino acids 826-1132) of human JAK2 expressed as N-terminal FLAG-tagged, biotinylated protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/3/2023
Entry Details
Go to US Patent

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