Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with all data for entry = 11270
TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604176(US11661410, No. 27 | 1-cyclopentyl-N-{6,7-dimethox...)
Affinity DataIC50: 8.32nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604224(US11661410, No. 286 | (3R,5S)-N-{6,7-dimethoxy- 1H...)
Affinity DataIC50: 10nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604184(US11661410, No. 35 | (3R)—N-[2, 3-dimethoxy-6...)
Affinity DataIC50: 11.5nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604232(US11661410, No. 409 | (3R,5R)-N-{6,7-dimethoxy- 1H...)
Affinity DataIC50: 12.6nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604220(US11661410, No. 149 | US11661410, No. 405 | (3R)-N...)
Affinity DataIC50: 12.6nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604179(US11661410, No. 30 | (3S)-N-{6,7-dimethoxy-1H,2H,3...)
Affinity DataIC50: 14.8nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604158(US11661410, No. 15 | N-{6,7-dimethoxy-1H,2H,3H-cyc...)
Affinity DataIC50: 21.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604150(US11661410, No. 10 | N-{6,7-dimethoxy-1H,2H,3H-cyc...)
Affinity DataIC50: 21.9nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604213(US11661410, No. 64 | (4R)-N-{6,7-dimethoxy-1H,2H,3...)
Affinity DataIC50: 25.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604197(US11661410, No. 48 | (3R)-N-{6,7-dimethoxy-1H,2H,3...)
Affinity DataIC50: 26.3nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604169(US11661410, No. 20 | 6,7-dimethoxy-N-{[1-(propan-2...)
Affinity DataIC50: 29.5nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604175(US11661410, No. 26 | N-{6-cyclopropyl-7-methoxy-1H...)
Affinity DataIC50: 29.5nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604146(US11661410, No. 7 | N-{6,7-dimethoxy-1H,2H,3H-cycl...)
Affinity DataIC50: 30.2nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604211(US11661410, No. 62 | (4R)-N-{6,7-dimethoxy-1H,2H,3...)
Affinity DataIC50: 31.6nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604212(US11661410, No. 63 | (4R)-N-{6,7-dimethoxy-1H,2H,3...)
Affinity DataIC50: 31.6nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604225(US11661410, No. 403 | 6,7-dimethoxy-N-{2-[(propan-...)
Affinity DataIC50: 31.6nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604151(US11661410, No. 11 | N-{6,7-dimethoxy-1H,2H,3H-cyc...)
Affinity DataIC50: 32.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604144(US11661410, No. 5 | (3R)—N-{6,7-dimethoxy-1H,...)
Affinity DataIC50: 36.3nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604209(US11661410, No. 60 | 1-cyclopentyl-N-{6,7-dimethox...)
Affinity DataIC50: 39.8nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604214(US11661410, No. 65 | 6,7-dimethoxy-N-[(pyrrolidin-...)
Affinity DataIC50: 39.8nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604148(US11661410, No. 9 | N-{6,7-dimethoxy-1H,2H,3H-cycl...)
Affinity DataIC50: 49nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604215(US11661410, No. 66 | 6,7-dimethoxy-N-[(pyrrolidin-...)
Affinity DataIC50: 50.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604188(US11661410, No. 39 | (3R)—N-[2, 3-dimethoxy-6...)
Affinity DataIC50: 53.7nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604161(US11661410, No. 16 | N-{6,7-dimethoxy-1H,2H,3H-cyc...)
Affinity DataIC50: 53.7nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604147(US11661410, No. 8 | N-[(azetidin-3-yl)methyl]-6,7-...)
Affinity DataIC50: 53.7nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604156(US11661410, No. 13 | N-{6,7-dimethoxy-1H,2H,3H-cyc...)
Affinity DataIC50: 60.3nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604220(US11661410, No. 149 | US11661410, No. 405 | (3R)-N...)
Affinity DataIC50: 63.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604237(US11661410, No. 414 | (3R)-N-{6,7-dimethoxy-1H,2H,...)
Affinity DataIC50: 63.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604223(US11661410, No. 402 | (3R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 79.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604218(US11661410, No. 69 | 6,7-dimethoxy-N-{(3S)-piperid...)
Affinity DataIC50: 79.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604195(US11661410, No. 46 | US11661410, No. 47 | (3R)...)
Affinity DataIC50: 79.4nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604194(US11661410, No. 45 | (3R,5R)—N-{6,7-dimethoxy...)
Affinity DataIC50: 85.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604172(US11661410, No. 23 | 1-benzyl-N-{6,7-dimethoxy-1H,...)
Affinity DataIC50: 89.1nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604216(US11661410, No. 67 | 6,7-dimethoxy-N-[(piperidin-4...)
Affinity DataIC50: 100nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604221(US11661410, No. 163 | (4R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 100nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604230(US11661410, No. 407 | (3R)-N-{6-ethoxy-7-methoxy- ...)
Affinity DataIC50: 100nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604217(US11661410, No. 68 | 6,7-dimethoxy-N-{[(3R)-piperi...)
Affinity DataIC50: 126nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604231(US11661410, No. 408 | (3S,5R)-N-{6,7-dimethoxy- 1H...)
Affinity DataIC50: 126nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604239(US11661410, No. 416 | (3R,5R)-N-{6,7-dimethoxy- 1H...)
Affinity DataIC50: 126nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604186(US11661410, No. 37 | (3R,5S)—N-{6,7-dimethoxy...)
Affinity DataIC50: 141nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604178(US11661410, No. 29 | (4R)—N-{6,7-dimethoxy-1H...)
Affinity DataIC50: 155nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604219(US11661410, No. 134 | N-[2,3-dimethoxy-6H,7H,8H- c...)
Affinity DataIC50: 158nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604221(US11661410, No. 163 | (4R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 158nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604195(US11661410, No. 46 | US11661410, No. 47 | (3R)...)
Affinity DataIC50: 178nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604192(US11661410, No. 43 | (3R)—N-{6-ethoxy-7-metho...)
Affinity DataIC50: 191nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604206(US11661410, No. 57 | N-{6-cyclopropyl-7-methoxy- 1...)
Affinity DataIC50: 191nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604210(US11661410, No. 61 | N-{6,7-dimethoxy-1H,2H,3H- cy...)
Affinity DataIC50: 200nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604177(US11661410, No. 28 | (4R)—N-{6,7-dimethoxy-1H...)
Affinity DataIC50: 219nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604226(US11661410, No. 404 | (3R)-N-[2,3-dimethoxy-6H,7H,...)
Affinity DataIC50: 251nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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TargetHistone-lysine N-methyltransferase EHMT2(Human)
Global Blood Therapeutics

US Patent
LigandPNGBDBM604202(US11661410, No. 53 | 2-[(7-methoxy-9-{[1-(propan-2...)
Affinity DataIC50: 288nMAssay Description:For the assay, the following buffer was used to set up reactions: 50 mM Tris-HCl pH9, 50 mM NaCl, 0.01% Tween-20 and 1 mM DTT (added fresh prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2023
Entry Details
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