Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 11143
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594184(US11584746, Compound I-2)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50529380(CHEMBL4533337 | US11584746, Compound I-1)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594186(US11584746, Compound I-4)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594185(US11584746, Compound I-3)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594189(US11584746, Compound I-7)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594194(US11584746, Compound I-11)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594201(US11584746, Compound I-18)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594200(US11584746, Compound I-17)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594205(US11584746, Compound I-22)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50529379(CHEMBL4530686 | US11584746, Compound I-21)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50529377(CHEMBL4558528 | US11584746, Compound I-20)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594209(US11584746, Compound I-a)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594208(US11584746, Compound I-25)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594207(US11584746, Compound I-24)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594206(US11584746, Compound I-23)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50529376(CHEMBL4520903 | US11584746, Compound I-b)
Affinity DataIC50: 250nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594199(US11584746, Compound I-16)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594198(US11584746, Compound I-15)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594188(US11584746, Compound I-6)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594187(US11584746, Compound I-5)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594202(US11584746, Compound I-19)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594193(US11584746, Compound I-10)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594192(US11584746, Compound I-9)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594190(US11584746, Compound I-8)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594197(US11584746, Compound I-14)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594196(US11584746, Compound I-13)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM594195(US11584746, Compound I-12)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined at both 1 μM and 1 mM ATP to identify both ATP competitive and non-competitive compounds. Hits were also counter-scr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent