Compile Data Set for Download or QSAR
Report error Found 142 Enz. Inhib. hit(s) with all data for entry = 10873
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM50546218(CHEMBL4741490 | US11466016, Example 114)
Affinity DataIC50: 3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575964(US11466016, Example 95 | (1R,2S,3S,5S)-8-[3-(5- ch...)
Affinity DataIC50: 3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575913(US11466016, Example 41 | exo-8-[7-(3,4- dichloro-2...)
Affinity DataIC50: 3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575962(US11466016, Example 93 | (1R,2S,3S,5S)-8-[3-(3,4- ...)
Affinity DataIC50: 3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575966(US11466016, Example 98 | {6-[(1R,2S,3S,5S)- 3-amin...)
Affinity DataIC50: 4nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575896(US11466016, Example 24 | endo-8-[7-(3,4- dichloro-...)
Affinity DataIC50: 4.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575937(US11466016, Example 66 | 5-{3-[endo-3-amino-8- aza...)
Affinity DataIC50: 4.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575965(US11466016, Example 96 | 7-{6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50: 4.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575995(US11466016, Example 129 | 5-{6- [(1R,2S,3S,5S)-3-...)
Affinity DataIC50: 5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575895(US11466016, Example 23 | 6-{3-[endo-3- amino-8- az...)
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575951(US11466016, Example 80 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575988(US11466016, Example 122 | {3- [(1R,2S,3S,5S)-3- am...)
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575983(US11466016, Example 118 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 5.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575915(US11466016, Example 43 | endo-8-{7-[7- chloro-2- (...)
Affinity DataIC50: 5.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575886(US11466016, Example 15 | endo-8-[7-(7- chloro-2- m...)
Affinity DataIC50: 5.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575908(US11466016, Example 36 | 2-(5-{3-[endo- 3-amino-8-...)
Affinity DataIC50: 6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575999(US11466016, Example 133 | {6-[endo-3-amino-8- aza...)
Affinity DataIC50: 6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576010(US11466016, Example 143 | {6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50: 6.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575884(US11466016, Example 13 | endo-8-[7-(7- chloro-1,3-...)
Affinity DataIC50: 6.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575975(US11466016, Example 108 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 6.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575941(US11466016, Example 69 | endo-8-(7-{4-chloro-2- [(...)
Affinity DataIC50: 6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575916(US11466016, Example 44 | (6-{3-[endo-3- amino-8- a...)
Affinity DataIC50: 6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575911(US11466016, Example 39 | endo-8-{7-[7- chloro-2- (...)
Affinity DataIC50: 6.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575977(US11466016, Example 110 | [6-(4-amino-4- methylpip...)
Affinity DataIC50: 7nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575991(US11466016, Example 125 | 6-[3,9- diazabicyclo[3....)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575959(US11466016, Example 88 | {6-[endo-3-amino-8- azabi...)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575934(US11466016, Example 62 | 5-{3-[endo-3-amino-8- aza...)
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575957(US11466016, Example 86 | {6-[3,8- diazabicyclo[3.2...)
Affinity DataIC50: 7.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575994(US11466016, Example 128 | {6-[endo-3- amino-8- az...)
Affinity DataIC50: 7.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575979(US11466016, Example 113 | {6-[endo-3-amino- 8-aza-...)
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576015(US11466016, Example 146 | (1S,2S,3S,5R)-8-[3- (7-...)
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575955(US11466016, Example 84 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575956(US11466016, Example 85 | {6-[(1S,2S,3S,5R)-3- amin...)
Affinity DataIC50: 7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575981(US11466016, Example 116 | {6-[endo-3-amino- 3-meth...)
Affinity DataIC50: 7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576009(US11466016, Example 140 | {6-[(1S,2S,3S,5R)- 3-am...)
Affinity DataIC50: 7.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575935(US11466016, Example 64 | (1R,2S,3S,5S)-8-[7-(4- ch...)
Affinity DataIC50: 7.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575958(US11466016, Example 87 | {6-[(1S,2S,3S,5R)-3- amin...)
Affinity DataIC50: 8nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575990(US11466016, Example 124 | 5-{6- [(1R,2S,3S,5S)-3-...)
Affinity DataIC50: 8.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575871(US11466016, Example 2 | exo-8-[7-(4- chloro-2- met...)
Affinity DataIC50: 8.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575961(US11466016, Example 92 | (1R,2S,3S,5S)-8-[3-(4- Ch...)
Affinity DataIC50: 8.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575954(US11466016, Example 83 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 8.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575942(US11466016, Example 70 | endo-8-(7-{4-chloro-2- [(...)
Affinity DataIC50: 8.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575982(US11466016, Example 117 | {3-[Chloro-3- (dimethyla...)
Affinity DataIC50: 8.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575997(US11466016, Example 131 | {6-[endo-3-amino-3- met...)
Affinity DataIC50: 8.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575972(US11466016, Example 105 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 8.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575970(US11466016, Example 103 | {6-[(1R,2S,3S,5S)- 3-ami...)
Affinity DataIC50: 8.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575876(US11466016, Example 6 | endo-9-[7-(4- chloro-2- me...)
Affinity DataIC50: 9nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576002(US11466016, Example 136 | 7-{6-[endo- 3-amino-8- ...)
Affinity DataIC50: 9nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575950(US11466016, Example 79 | {6-[(1R,2S,3S,5S)-3- amin...)
Affinity DataIC50: 9.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM575996(US11466016, Example 130 | {6-[(1S,2S,3S,5R)- 3-am...)
Affinity DataIC50: 9.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

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