Compile Data Set for Download or QSAR
Report error Found 55 Enz. Inhib. hit(s) with all data for entry = 10821
TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataEC50:  88.2nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571414((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataEC50:  107nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571416({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  64.5nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571417((2,5-dimethylfuran-3- yl)[(4E)-4-{3-[3- (hydroxyme...)
Affinity DataEC50:  37.4nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571423((3-chlorophenyl)[(4E)-4- {[5-(3-chlorophenyl)-1H- ...)
Affinity DataEC50:  121nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)
Affinity DataEC50:  52.8nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571426((3-chlorophenyl){(4E)-4- {3-[3- (hydroxymethyl)phe...)
Affinity DataEC50:  49.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571427((3-chlorophenyl){(4E)-4- [3-(4-fluorophenyl)prop-2...)
Affinity DataEC50:  38.6nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571434({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  115nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571428({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  165nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571429({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  51.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571430({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  23nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571431((3-chlorophenyl){(4E)-4- [3-(3-hydroxyphenyl)prop-...)
Affinity DataEC50:  224nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571436(3-{(3E)-3-[1-(3- methoxybenzoyl)-3,3- dimethylpipe...)
Affinity DataEC50:  87.7nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571432(3-[(3E)-3-{1-[(2,5- dimethylfuran-3- yl)carbonyl]-...)
Affinity DataEC50:  291nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571435({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataEC50:  268nMAssay Description:The PAM potency was evaluated by performing an agonist concentration response curve in the presence of the compounds. The compounds at fixed concentr...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571418(ethyl (3E)-2,2-dimethyl-3- [3-(6-methylpyridin-2- ...)
Affinity DataIC50: 2.02nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
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Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571410(ethyl (4E)-4-[3-(3- cyanophenyl)prop-2-yn-1- ylide...)
Affinity DataIC50: 8.60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571412(ethyl (4E)-4-[3-(4- cyanopyridin-2-yl)prop-2- yn-1...)
Affinity DataIC50: 13.5nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571415(methyl (4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- yli...)
Affinity DataIC50: 18.2nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571421(ethyl (3E)-3-[3-(4- chloropyridin-2-yl)prop-2- yn-...)
Affinity DataIC50: 31.6nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571409(ethyl (4E)-4-[3-(4- methoxypyridin-2-yl)prop- 2-yn...)
Affinity DataIC50: 31.8nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571411(ethyl (4E)-4-{3-[3- (cyanomethyl)phenyl]prop- 2-yn...)
Affinity DataIC50: 37.2nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571413(ethyl (4E)-4-[3-(3-cyano-5- fluorophenyl)prop-2-yn...)
Affinity DataIC50: 60nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571422(ethyl (3E)-3-[3-(3- chlorophenyl)prop-2-yn-1- ylid...)
Affinity DataIC50: 66.3nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571408(ethyl (4E)-3,3-dimethyl-4- {3-[3- (trifluoromethyl...)
Affinity DataIC50: 66.3nMAssay Description:Cells were seeded into black-walled, clear-bottom, 96-well plates at a density of 80000 cell/well, in RPMI (without Phenol Red, without L-glutamine; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571410(ethyl (4E)-4-[3-(3- cyanophenyl)prop-2-yn-1- ylide...)
Affinity DataKi:  0.640nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571399(ethyl (4E)-4-[3-(2,5- difluorophenyl)prop-2-yn- 1-...)
Affinity DataKi:  0.890nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571414((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataKi:  0.990nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571398(ethyl (4E)-4-[3-(4- chloropyridin-2-yl)prop-2- yn-...)
Affinity DataKi:  1.01nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571415(methyl (4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- yli...)
Affinity DataKi:  1.29nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571397(ethyl (4E)-3,3-dimethyl-4- [3-(6-methylpyridin-2- ...)
Affinity DataKi:  1.47nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571425(3-{(3E)-3-[1-(3- chlorobenzoyl)-3,3- dimethylpiper...)
Affinity DataKi:  1.60nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571428({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataKi:  1.82nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571408(ethyl (4E)-3,3-dimethyl-4- {3-[3- (trifluoromethyl...)
Affinity DataKi:  1.90nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571433((3-chlorophenyl){(4E)-4- [3-(3-chlorophenyl)prop-2...)
Affinity DataKi:  1.91nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571411(ethyl (4E)-4-{3-[3- (cyanomethyl)phenyl]prop- 2-yn...)
Affinity DataKi:  2.12nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571429({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataKi:  2.24nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571430({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataKi:  2.42nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571418(ethyl (3E)-2,2-dimethyl-3- [3-(6-methylpyridin-2- ...)
Affinity DataKi:  2.44nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571412(ethyl (4E)-4-[3-(4- cyanopyridin-2-yl)prop-2- yn-1...)
Affinity DataKi:  2.93nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571427((3-chlorophenyl){(4E)-4- [3-(4-fluorophenyl)prop-2...)
Affinity DataKi:  4.02nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571431((3-chlorophenyl){(4E)-4- [3-(3-hydroxyphenyl)prop-...)
Affinity DataKi:  7.35nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571416({(4E)-4-[3-(3- chlorophenyl)prop-2-yn-1- ylidene]-...)
Affinity DataKi:  7.39nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571426((3-chlorophenyl){(4E)-4- {3-[3- (hydroxymethyl)phe...)
Affinity DataKi:  8.05nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571422(ethyl (3E)-3-[3-(3- chlorophenyl)prop-2-yn-1- ylid...)
Affinity DataKi:  11.2nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571413(ethyl (4E)-4-[3-(3-cyano-5- fluorophenyl)prop-2-yn...)
Affinity DataKi:  16.1nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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US Patent
LigandPNGBDBM571421(ethyl (3E)-3-[3-(4- chloropyridin-2-yl)prop-2- yn-...)
Affinity DataKi:  16.3nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571424(2-methyl-6-[3-(2,2,6,6- tetramethylpiperidin-4- yl...)
Affinity DataKi:  26.9nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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TargetMetabotropic glutamate receptor 5(Human)
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LigandPNGBDBM571409(ethyl (4E)-4-[3-(4- methoxypyridin-2-yl)prop- 2-yn...)
Affinity DataKi:  28.6nMAssay Description:Affinity at transmembrane glutamate metabotropic cloned human mGluR5 receptor was evaluated according to the methods of Anderson (Anderson et al., J ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2022
Entry Details
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