Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 10216
TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataIC50: 2.20nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM50241107(CHEMBL219916 | 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro...)
Affinity DataIC50: 3.40nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM86721(CAS_51152-91-1 | NSC_37459 | BUTACLAMOL | US111478...)
Affinity DataIC50: 6.40nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM48320(SMR000058471 | METOCLOPRAMIDE | METOCLOPRAMIDE HYD...)
Affinity DataIC50: 280nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM179868(US9132134, Metopimazine-Acid (NG102) | US11147820,...)
Affinity DataIC50: 310nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  0.0700nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(3) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  0.610nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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Target5-hydroxytryptamine receptor 2A(Human)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  1.5nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetD(1A) dopamine receptor(Human)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  1.90nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
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TargetHistamine H1 receptor(Guinea pig)
Neurogastrx

US Patent
LigandPNGBDBM179867(US9132134, Metopimazine (NG101) | US11147820, Comp...)
Affinity DataKi:  8.40nMAssay Description:For the radioligand binding assay, cell membranes of dopamine D2 receptor expressing cells were incubated with [3H]spiperone and competing drugs in b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2022
Entry Details
Go to US Patent