Compile Data Set for Download or QSAR
Report error Found 91 Enz. Inhib. hit(s) with all data for entry = 10270
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413448(US10407446, Example 1 | 9-((1r,4r)-4-hydroxycycloh...)
Affinity DataIC50: 0.100nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413454(US10407446, Example 7 | (S)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413449(US10407446, Example 2 | 9-((1s,4s)-4-hydroxycycloh...)
Affinity DataIC50: 0.158nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 0.200nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413453(US10407446, Example 6 | 9-((1r,4r)-methoxycyclohex...)
Affinity DataIC50: 0.251nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 0.316nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 0.398nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413455(US10407446, Example 8 | (R)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 0.398nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 0.501nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413450(US10407446, Example 3 | 7-methyl-2-((7-methyl-[1,2...)
Affinity DataIC50: 0.631nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413452(US10407446, Example 5 | 9-((1s,4s)-4-methoxycycloh...)
Affinity DataIC50: 1nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDNA-dependent protein kinase catalytic subunit(Human)
Astrazeneca

US Patent
LigandPNGBDBM413451(US10407446, Example 4 | 2-((2,7-dimethyl-[1,2,4]tr...)
Affinity DataIC50: 1.26nMAssay Description:The inhibitory activity of compounds against DNAPK was determined by TR-FRET measuring a fluorescent labelled peptide substrate converting to a phosp...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 501nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413449(US10407446, Example 2 | 9-((1s,4s)-4-hydroxycycloh...)
Affinity DataIC50: 794nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413453(US10407446, Example 6 | 9-((1r,4r)-methoxycyclohex...)
Affinity DataIC50: 1.26E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.59E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413448(US10407446, Example 1 | 9-((1r,4r)-4-hydroxycycloh...)
Affinity DataIC50: 3.16E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 3.98E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413452(US10407446, Example 5 | 9-((1s,4s)-4-methoxycycloh...)
Affinity DataIC50: 5.01E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413450(US10407446, Example 3 | 7-methyl-2-((7-methyl-[1,2...)
Affinity DataIC50: 5.01E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413455(US10407446, Example 8 | (R)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 6.31E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413454(US10407446, Example 7 | (S)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 6.31E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 7.94E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetDual specificity protein kinase TTK(Human)
Astrazeneca

US Patent
LigandPNGBDBM413451(US10407446, Example 4 | 2-((2,7-dimethyl-[1,2,4]tr...)
Affinity DataIC50: 7.94E+3nMAssay Description:The inhibitory activity of compounds against TTK was determined in a LanthaScreen Eu Kinase Binding assay run by ThermoFisher Scientific as part of t...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413455(US10407446, Example 8 | (R)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413455(US10407446, Example 8 | (R)-7-methyl-2-((7-methyl-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413456(US10407446, Example 9 | 9-((1r,4r)-4-hydroxy-4-met...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413460(US10407446, Example 13 | 9-cyclohexyl-7-methyl-2-(...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413459(US10407446, Example 12 | 9-((1s,4s)-4-hydroxy-1-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413457(US10407446, Example 10 | 9-((1s,4s)-4-hydroxy-4-me...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/27/2022
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

US Patent
LigandPNGBDBM413458(US10407446, Example 11 | (S)-7-methyl-2-((7-methyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activity of compounds against AURKA, AURKB, JAK1, JAK2 and JAK3 was determined in Z'-LYTE assays run by ThermoFisher Scientific as...More data for this Ligand-Target Pair
Ligand InfoSimilars
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Date in BDB:
3/27/2022
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