Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 9973
TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334643(US9732075, Example 4.100 | [(2S,3S)-2-(6-Chloro-4-...)
Affinity DataIC50: 2nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504777([(S)-2-Methyl-2-(4-methyl-1H-benzoimidazol-2-yl)-p...)
Affinity DataIC50: 13nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334957(US9732075, Example 5.217 | [(S)-2-(5-Chloro-4-meth...)
Affinity DataIC50: 15nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US9732075, Example 2.8 | [(S)-2-(5-Chloro-4-methyl...)
Affinity DataIC50: 17nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US9732075, Example 2.8 | [(S)-2-(5-Chloro-4-methyl...)
Affinity DataIC50: 18nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505080((6-Benzo[1,3]dioxol-5-yl-2-fluoro-3-methoxy-phenyl...)
Affinity DataIC50: 19nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504777([(S)-2-Methyl-2-(4-methyl-1H-benzoimidazol-2-yl)-p...)
Affinity DataIC50: 26nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504590([(2S,3S)-3-Methyl-2-(4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 29nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505087([5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-[(S)-2...)
Affinity DataIC50: 33nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334957(US9732075, Example 5.217 | [(S)-2-(5-Chloro-4-meth...)
Affinity DataIC50: 45nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505340({(S)-2-[1-(2-Methoxy-ethyl)-5,6-dimethyl-1H-benzoi...)
Affinity DataIC50: 46nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335238(US9732075, Example 6.191 | [(S)-2-(5,6-Dimethyl-1H...)
Affinity DataIC50: 48nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504523([(2S,4S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 53nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504523([(2S,4S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 56nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505004([(S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-2...)
Affinity DataIC50: 56nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504534([(2S,4S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 69nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504474([4-(4-Bromo-3-chloro-phenyl)-pyrimidin-5-yl]-[(S)-...)
Affinity DataIC50: 80nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505080((6-Benzo[1,3]dioxol-5-yl-2-fluoro-3-methoxy-phenyl...)
Affinity DataIC50: 86nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504534([(2S,4S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 102nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504318((5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(4-...)
Affinity DataIC50: 108nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505340({(S)-2-[1-(2-Methoxy-ethyl)-5,6-dimethyl-1H-benzoi...)
Affinity DataIC50: 190nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505087([5-(4-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-[(S)-2...)
Affinity DataIC50: 367nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504474([4-(4-Bromo-3-chloro-phenyl)-pyrimidin-5-yl]-[(S)-...)
Affinity DataIC50: 726nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504590([(2S,3S)-3-Methyl-2-(4-methyl-1H-benzoimidazol-2-y...)
Affinity DataIC50: 778nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334643(US9732075, Example 4.100 | [(2S,3S)-2-(6-Chloro-4-...)
Affinity DataIC50: 833nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM504318((5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(4-...)
Affinity DataIC50: 1.50E+3nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM505004([(S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-2...)
Affinity DataIC50: 2.03E+3nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
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