Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 9841
TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492900(US10981893, Example 29 | N-((3-chloro-1H-indol- 5-...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492896(US10981893, Example 25 | N-((6-amino-2,4- dimethyl...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492894(US10981893, Example 23 | N-((6-amino-2- methylpyri...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(US10981893, Example 22 | N-((6-amino-2,4- dimethyl...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492892(US10981893, Example 21 | N-((6-amino-2,4- dimethyl...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492899(US10981893, Example 28 | N-((6-amino-2- methylpyri...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492892(US10981893, Example 21 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(US10981893, Example 22 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492894(US10981893, Example 23 | N-((6-amino-2- methylpyri...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492895(US10981893, Example 24 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492896(US10981893, Example 25 | N-((6-amino-2,4- dimethyl...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492900(US10981893, Example 29 | N-((3-chloro-1H-indol- 5-...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492901(US10981893, Example 30 | N-((5-chloro-1H- indazol-...)
Affinity DataIC50: 100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492898(US10981893, Example 27 | N-((6-amino-4- (trifluoro...)
Affinity DataIC50: 550nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492891(US10981893, Example 20 | N-((3- aminobenzo[d]isoxa...)
Affinity DataIC50: 550nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492897(US10981893, Example 26 | N-((6-amino-2- (trifluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492873(US10981893, Example 2 | N-((5-chloro-1H- indazol-3...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492872(US10981893, Example 1 | N-((5-chloro-1H- indazol-3...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492888(US10981893, Example 17 | N-((3-chloro-6-fluoro- 1H...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492887(US10981893, Example 16 | N-(4-methoxybenzyl)- 5-(4...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492886(US10981893, Example 15 | N-(4-chlorobenzyl)-5- (4-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492885(US10981893, Example 14 | N-(4-carbamoylbenzyl)- 5-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492884(US10981893, Example 13 | N-((5-chloro-1H- indazol-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492883(US10981893, Example 12 | 2-(5-chloro-1H-indazol- 3...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492882(US10981893, Example 11 | N-(2-amino-1-(5- chloro-1...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492874(US10981893, Example 3 | N-((5-chloro-1H- indazol-3...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492875(US10981893, Example 4 | N-((5-chloro-1H- indazol-3...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492876(US10981893, Example 5 | 5-benzyl-N-((5-chloro- 1H-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492878(US10981893, Example 7 | N-((3-chloro-6-fluoro- 1H-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492877(US10981893, Example 6 | 5-(2-carbamoylbenzyl)- N-(...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492881(US10981893, Example 10 | N-((5-chloro-1H- indazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492879(US10981893, Example 8 | 5-((4-carbamoyl-1H- pyrazo...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492880(US10981893, Example 9 | N-((3-chloro-6-fluoro- 1H-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492889(US10981893, Example 18 | N-(4-bromo-3- fluorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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TargetPlasma kallikrein(Human)
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492890(US10981893, Example 19 | N-(4-cyano-2- methylbenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
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