Compile Data Set for Download or QSAR
Report error Found 332 Enz. Inhib. hit(s) with all data for entry = 9813
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490338(US10968216, Example 6 | N-(2-chloro-6-fluorophenyl...)
Affinity DataIC50: 1nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490402(US10968216, Example 70 | 5-fluoro-N-(2-methylpheny...)
Affinity DataIC50: 1nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490556(US10968216, Example 224 | 5-fluoro-N-(2-methylphen...)
Affinity DataIC50: 1nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490548(US10968216, Example 216 | 5-fluoro-4-(3-oxo[1,2,4]...)
Affinity DataIC50: 1.20nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490357(US10968216, Example 25 | 5-fluoro-N-[2-(methylamin...)
Affinity DataIC50: 1.5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490359(US10968216, Example 27 | N-(4-amino-2-methylphenyl...)
Affinity DataIC50: 1.70nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490359(US10968216, Example 27 | N-(4-amino-2-methylphenyl...)
Affinity DataIC50: 1.80nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490333(US10968216, Example 1 | N-(2,6-difluorophenyl)-5-f...)
Affinity DataIC50: 2nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490360(US10968216, Example 28 | 5-fluoro-N-(2-fluoro-6-me...)
Affinity DataIC50: 2nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490393(US10968216, Example 61 | N-(2-chloro-6-methylpheny...)
Affinity DataIC50: 2nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490403(US10968216, Example 71 | 5-fluoro-N-(2-fluoro-6-me...)
Affinity DataIC50: 2nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490477(US10968216, Example 145 | N-(5-amino-3-methylpyrid...)
Affinity DataIC50: 2nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490481(US10968216, Example 149 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 2nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490471(US10968216, Example 139 | N-(3-amino-2-methylpheny...)
Affinity DataIC50: 2.40nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490450(US10968216, Example 118 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 2.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490478(US10968216, Example 146 | 2-({2-[(1S)-1-cyclohexyl...)
Affinity DataIC50: 2.5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490347(US10968216, Example 15 | 5-fluoro-N-[2-methyl-6-(t...)
Affinity DataIC50: 2.70nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490467(US10968216, Example 135 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 2.90nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490564(US10968216, Example 232 | N-(2-chloro-4-fluoro-6-m...)
Affinity DataIC50: 2.90nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490339(US10968216, Example 7 | 5-fluoro-N-(2-methylphenyl...)
Affinity DataIC50: 3nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490361(US10968216, Example 29 | N-(2,6-difluorophenyl)-5-...)
Affinity DataIC50: 3nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490394(US10968216, Example 62 | N-(2-chloro-4-fluoro-6-me...)
Affinity DataIC50: 3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490483(US10968216, Example 151 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 3nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490560(US10968216, Example 228 | N-(2-chloro-6-fluorophen...)
Affinity DataIC50: 3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490563(US10968216, Example 231 | N-(2,6-dichlorophenyl)-5...)
Affinity DataIC50: 3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490565(US10968216, Example 233 | N-(2-chloro-6-methylphen...)
Affinity DataIC50: 3.20nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490448(US10968216, Example 116 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 3.30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490622(US10968216, Example 290 | N-(2,6-difluoro-4-hydrox...)
Affinity DataIC50: 3.40nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490382(US10968216, Example 50 | N-(2-chloro-6-fluoropheny...)
Affinity DataIC50: 3.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490555(US10968216, Example 223 | 5-fluoro-N-(2-fluorophen...)
Affinity DataIC50: 3.80nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490568(US10968216, Example 236 | N-(2,6-dichloro-4-fluoro...)
Affinity DataIC50: 4.10nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490396(US10968216, Example 64 | 5-fluoro-N-(4-fluoro-2,6-...)
Affinity DataIC50: 4.30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490340(US10968216, Example 8 | 5-fluoro-N-(4-fluoro-2-met...)
Affinity DataIC50: 4.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490411(US10968216, Example 79 | N-(2,6-dichlorophenyl)-5-...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490420(US10968216, Example 88 | 5-fluoro-N-[2-methyl-6-(t...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490472(US10968216, Example 140 | N-[4-amino-2-(trifluorom...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490484(US10968216, Example 152 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490489(US10968216, Example 157 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490498(US10968216, Example 166 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490501(US10968216, Example 169 | N-(2-chloro-6-fluorophen...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490549(US10968216, Example 217 | 5-fluoro-N-(2-fluoro-6-m...)
Affinity DataIC50: 5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490567(US10968216, Example 235 | 5-fluoro-N-[2-methyl-6-(...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490594(US10968216, Example 262 | N-(2,6-difluorophenyl)-5...)
Affinity DataIC50: 5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490595(US10968216, Example 263 | 5-fluoro-N-(2-fluoro-6-m...)
Affinity DataIC50: 5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490348(US10968216, Example 16 | N-[2-(difluoromethyl)phen...)
Affinity DataIC50: 5.10nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490518(US10968216, Example 186 | N-(2,6-dichlorophenyl)-5...)
Affinity DataIC50: 5.30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490343(US10968216, Example 11 | 5-fluoro-N-(2-methoxy-4-m...)
Affinity DataIC50: 5.80nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490401(US10968216, Example 69 | 5-fluoro-N-(2-methoxy-6-m...)
Affinity DataIC50: 6nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
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Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490551(US10968216, Example 219 | 5-fluoro-N-(2-methylphen...)
Affinity DataIC50: 6nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490487(US10968216, Example 155 | 2-[(1S)-1-cyclohexyletho...)
Affinity DataIC50: 6.05nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

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