Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 9664
TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(US10899741, Example 1 | 4-(1-Cyclobutyl-3-(6-methy...)
Affinity DataIC50: 208nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
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Date in BDB:
8/15/2021
Entry Details
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TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480002(US10899741, Example 3 | 4-(1-Cyclopentyl-3-(6-meth...)
Affinity DataIC50: 241nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 270nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetTGF-beta receptor type-1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480003(US10899741, Example 8 | (R)-4-(3-(6-Methylpyridin-...)
Affinity DataIC50: 370nMAssay Description:TGFβRI kinase assay kit (V4093, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 1.00E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
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Date in BDB:
8/15/2021
Entry Details
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TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(US10899741, Example 1 | 4-(1-Cyclobutyl-3-(6-methy...)
Affinity DataIC50: 1.20E+3nMAssay Description:RIPK2 kinase assay kit (V4084, Promega) was used to assay enzyme activity. 2 μl of RIPK2 enzyme solution (the final concentration of enzyme in t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(US10899741, Example 1 | 4-(1-Cyclobutyl-3-(6-methy...)
Affinity DataIC50: 2.20E+3nMAssay Description:p38α kinase assay kit (V9591, Promega) was used to assay enzyme activity. 2 μl of enzyme solution (the final concentration of enzyme in the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM479981(US10899741, Example 1 | 4-(1-Cyclobutyl-3-(6-methy...)
Affinity DataIC50: 2.50E+3nMAssay Description:VEGFR2: Z'-LYTEC Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM480001(US10899741, Example 2 | 4-(1-Cyclopropyl-3-(6-meth...)
Affinity DataIC50: 4.20E+3nMAssay Description:VEGFR2: Z'-LYTEC Kinase Assay Kit—Tyrosine 1 Peptide (PV3190, Invitrogen) was used to assay enzyme activity. 5 μl of recombinant human ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent