Compile Data Set for Download or QSAR
Report error Found 120 Enz. Inhib. hit(s) with all data for entry = 9642
TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477924(US10889581, Example 127 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 2nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477925(US10889581, Example 128 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 2nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477920(US10889581, Example 123 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 3nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477913(US10889581, Example 116 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 5nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477915(US10889581, Example 118 | (E)-3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 6nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477926(US10889581, Example 129 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 7nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477929(US10889581, Example 132 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 7nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477918(US10889581, Example 121 | 2-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 9nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477919(US10889581, Example 122 | 4-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 10nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477917(US10889581, Example 120 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 11nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477934(US10889581, Example 137 | 6-((5-((1S,5S)-3-amino-5...)
Affinity DataIC50: 11nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477914(US10889581, Example 117 | (E)-3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 12nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477915(US10889581, Example 118 | (E)-3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 17nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477908(US10889581, Example 111 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 19nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477929(US10889581, Example 132 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 20nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477914(US10889581, Example 117 | (E)-3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 21nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477923(US10889581, Example 126 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 21nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477932(US10889581, Example 135 | 6-((3-((1S,5S)-3-amino-1...)
Affinity DataIC50: 23nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477909(US10889581, Example 112 | (E)-3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 25nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477921(US10889581, Example 124 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 37nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477933(US10889581, Example 136 | 6-((5-((1S,5S)-3-amino-5...)
Affinity DataIC50: 37nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477901(US10889581, Example 104 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 38nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477928(US10889581, Example 131 | (1S,5S,6S)-3-amino-5-(2-...)
Affinity DataIC50: 41nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477904(US10889581, Example 107 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 47nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477907(US10889581, Example 110 | 6-((3-((1S,5S,6R)-3-amin...)
Affinity DataIC50: 47nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477918(US10889581, Example 121 | 2-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 47nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477916(US10889581, Example 119 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 49nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477921(US10889581, Example 124 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 49nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477906(US10889581, Example 109 | 2-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 57nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477924(US10889581, Example 127 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 77nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477935(US10889581, Example 138 | (1S,5S,6S)-5-(5-((4-chlo...)
Affinity DataIC50: 77nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477897(US10889581, Example 100 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 80nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477903(US10889581, Example 106 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 84nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477900(US10889581, Example 103 | 5-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 86nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477906(US10889581, Example 109 | 2-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 92nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477902(US10889581, Example 105 | (1S,5S,6S)-5-(5-((5-(but...)
Affinity DataIC50: 96nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477930(US10889581, Example 133 | 6-((3-((1S,5S)-3-amino-1...)
Affinity DataIC50: 97nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477920(US10889581, Example 123 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 99nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477898(US10889581, Example 101 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 104nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477912(US10889581, Example 115 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 109nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477910(US10889581, Example 113 | 2-((1R,5S,6S)-3-amino-5-...)
Affinity DataIC50: 116nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477916(US10889581, Example 119 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 126nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477931(US10889581, Example 134 | (1S,5S)-5-(5-((5-chloro-...)
Affinity DataIC50: 129nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477936(US10889581, Example 123d | (1S,5S,6S)-3-amino-5-(5...)
Affinity DataIC50: 142nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477927(US10889581, Example 130 | (1S,5S,6S)-3-amino-5-(2-...)
Affinity DataIC50: 161nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477913(US10889581, Example 116 | 6-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 166nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477917(US10889581, Example 120 | 6-((3-((1S,5S,6S)-3-amin...)
Affinity DataIC50: 179nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM477899(US10889581, Example 102 | (1S,5S,6S)-5-(5-((5-chlo...)
Affinity DataIC50: 182nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477926(US10889581, Example 129 | (1S,5S,6S)-3-amino-5-(5-...)
Affinity DataIC50: 251nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Amgen

US Patent
LigandPNGBDBM477919(US10889581, Example 122 | 4-((3-((1R,5S,6S)-3-amin...)
Affinity DataIC50: 281nMAssay Description:The cDNAs for both human recombinant BACE1 and 2 with C-terminal 6-His Tags were cloned into transient protein expression vectors, which were subsequ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2021
Entry Details
Go to US Patent

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