Compile Data Set for Download or QSAR
Report error Found 268 Enz. Inhib. hit(s) with all data for entry = 9489
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(US10815215, Example 17 | 4-(3-ethyl-4-methyl-5-oxo...)
Affinity DataIC50: 1nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470561(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...)
Affinity DataIC50: 1nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470552(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...)
Affinity DataIC50: 1.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470555(1-(4-[(2,6-dichlorophenyl)carbamoyl]-2-fluoro-5-{[...)
Affinity DataIC50: 1.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470513(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50: 1.80nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470565(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...)
Affinity DataIC50: 2nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470524(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50: 2.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470377(US10815215, Example 36 | 4-(3-ethyl-4-methyl-5-oxo...)
Affinity DataIC50: 2.80nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470522(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50: 2.80nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470359(US10815215, Example 18 | N-(2,6-difluorophenyl)-4-...)
Affinity DataIC50: 3nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470466(N-(2,6-dichlorophenyl)-4-[4-ethyl-3-(hydroxymethyl...)
Affinity DataIC50: 3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470568(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...)
Affinity DataIC50: 3nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470472(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50: 3.20nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470471(N-(2,6-dichlorophenyl)-5-fluoro-4-{3-[(1S)-1-hydro...)
Affinity DataIC50: 3.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470516(N-(2-chloro-6-fluorophenyl)-4-[3-(2-hydroxypropan-...)
Affinity DataIC50: 3.90nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470454(N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...)
Affinity DataIC50: 4.17nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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PDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470532(N-(2-chloro-6-fluoro-4-hydroxyphenyl)-4-[4-ethyl-3...)
Affinity DataIC50: 4.30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470465(N-(2,6-dichlorophenyl)-5-fluoro-4-[3-(hydroxymethy...)
Affinity DataIC50: 4.33nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470462(4-[4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...)
Affinity DataIC50: 4.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470467(N-(2,6-dichlorophenyl)-5-fluoro-4-[3-(2-hydroxypro...)
Affinity DataIC50: 4.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470474(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(2-hydro...)
Affinity DataIC50: 4.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470480(5-fluoro-N-(2-fluoro-6-methylphenyl)-4-[3-(2-hydro...)
Affinity DataIC50: 4.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470407(5-fluoro-N-(2-fluoro-6-methylphenyl)-4-[4-methyl-5...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470473(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-{3-[(1S)-1-...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470530(N-(6-chloro-2-fluoro-3-hydroxyphenyl)-4-[4-ethyl-3...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470533(N-(2-chloro-6-fluoro-3-methoxyphenyl)-4-[4-ethyl-3...)
Affinity DataIC50: 5.20nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470534(N-(2-chloro-6-fluoro-3-hydroxyphenyl)-4-[4-ethyl-3...)
Affinity DataIC50: 5.20nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470357(US10815215, Example 16 | 4-(3-ethyl-4-methyl-5-oxo...)
Affinity DataIC50: 5.33nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470365(US10815215, Example 24 | N-(3-amino-2-methylphenyl...)
Affinity DataIC50: 5.40nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470380(US10815215, Example 39 | 4-(3-ethyl-4-methyl-5-oxo...)
Affinity DataIC50: 5.5nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470463(5-fluoro-N-(2-fluoro-6-methylphenyl)-4-[3-(2-hydro...)
Affinity DataIC50: 5.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470358(US10815215, Example 17 | 4-(3-ethyl-4-methyl-5-oxo...)
Affinity DataIC50: 6nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470518(N-(2-chloro-6-fluorophenyl)-4-[4-ethyl-3-(hydroxym...)
Affinity DataIC50: 6nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470551(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-3-{[(2S)...)
Affinity DataIC50: 6nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470395(US10815215, Example 54 | 4-(3-cyclopropyl-4-ethyl-...)
Affinity DataIC50: 6.05nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470453(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(2-hydro...)
Affinity DataIC50: 6.17nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470558(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-2-fluoro...)
Affinity DataIC50: 6.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470479(5-fluoro-N-(2-fluoro-6-methylphenyl)-4-{3-[(1S)-1-...)
Affinity DataIC50: 7nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470523(N-(2-chloro-6-fluorophenyl)-4-[4-cyclobutyl-3-(hyd...)
Affinity DataIC50: 7nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470562(1-(4-[(2-chloro-6-fluorophenyl)carbamoyl]-5-{[3,3-...)
Affinity DataIC50: 7nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470389(US10815215, Example 48 | 4-(3-cyclopropyl-4-methyl...)
Affinity DataIC50: 7.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470478(5-fluoro-N-(2-fluoro-6-methylphenyl)-4-[3-(hydroxy...)
Affinity DataIC50: 7.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470564(1-(4-[(2,6-difluorophenyl)carbamoyl]-2-fluoro-5-{[...)
Affinity DataIC50: 7.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470412(4-(3-ethyl-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-tri...)
Affinity DataIC50: 7.75nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470349(US10815215, Example 11 | 5-fluoro-N-(2-fluoro-6-me...)
Affinity DataIC50: 8nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470554(4-ethyl-1-(2-fluoro-4-[(2-fluoro-6-methylphenyl)ca...)
Affinity DataIC50: 8.5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470339(US10815215, Example 1 | 5-fluoro-4-[3-methyl-5-oxo...)
Affinity DataIC50: 9nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
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Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470553(1-(4-[(2,6-difluorophenyl)carbamoyl]-3-{[(2S)-1,1,...)
Affinity DataIC50: 9nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470452(N-(2-chloro-6-fluorophenyl)-5-fluoro-4-[3-(hydroxy...)
Affinity DataIC50: 9.75nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM470525(N-(2-chloro-6-fluorophenyl)-2-{[3,3-difluorobutan-...)
Affinity DataIC50: 10nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
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