Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with all data for entry = 9377
TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 0.0700nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 0.120nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237900(US9394282, 9-35 | US10766883, Comp. Ex-4 9-35)
Affinity DataIC50: 0.150nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237868(US9394282, 9-20 | US9394282, 9-3 | US10766883, Com...)
Affinity DataIC50: 0.160nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462088(1-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-3-((3...)
Affinity DataIC50: 0.160nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237869(US9394282, 9-4 | US10766883, Comp. Ex-1 9-4)
Affinity DataIC50: 0.170nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462084(3-((4-chloro-3- (methylthio)phenyl)amino)-1- ((3R,...)
Affinity DataIC50: 0.25nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462087(3-((4-cyano-3- isopropylphenyl)amino)-1-((3R,4S)- ...)
Affinity DataIC50: 0.490nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237900(US9394282, 9-35 | US10766883, Comp. Ex-4 9-35)
Affinity DataIC50: 1.24nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237868(US9394282, 9-20 | US9394282, 9-3 | US10766883, Com...)
Affinity DataIC50: 1.35nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237869(US9394282, 9-4 | US10766883, Comp. Ex-1 9-4)
Affinity DataIC50: 1.92nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237875(US9394282, 9-10 | US10766883, Comp. Ex-2 9-10)
Affinity DataIC50: 2.09nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462088(1-((3R,4S)-4-cyanotetrahydro-2H- pyran-3-yl)-3-((3...)
Affinity DataIC50: 3.04nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50250923(CHEMBL4072848 | US10766883, Ex-3)
Affinity DataIC50: 3.28nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50250927(CHEMBL4071005 | US10766883, Ex-1)
Affinity DataIC50: 3.88nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462084(3-((4-chloro-3- (methylthio)phenyl)amino)-1- ((3R,...)
Affinity DataIC50: 5.48nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM462087(3-((4-cyano-3- isopropylphenyl)amino)-1-((3R,4S)- ...)
Affinity DataIC50: 9.70nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM237875(US9394282, 9-10 | US10766883, Comp. Ex-2 9-10)
Affinity DataIC50: 23.4nMAssay Description:The basic assay protocol is as follows: First, 250 nL of diluted compounds in DMSO were dispensed into the wells of a dry 384-well Black plate (Grein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent