Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 9347
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 18.7nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 28nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 40nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 89nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 192nMAssay Description:human ROMK and rat ROMK: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, Invitrogen) (2) Ouabain (03125-1G, Sigma)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 4.37E+4nMAssay Description:hERG: 1. Materials and Instruments (1) FluxOR potassium ion channel assay (F10016, invitrogen) (2) FlexStation3 microplate reader (molecular de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent