Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 9031
TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436099(US10590077, Example 1 | 4-(((3S,4R)-1-((2,4-dichlo...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
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TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436104(US10590077, Example 5 | 4-(((3S,4R)-1- ((2-cyano-4...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
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TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436105(US10590077, Example 6 | 4-(((3S,4R)-1- ((2-chloro-...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436106(US10590077, Example 7 | 4-(((3S,4S)-4-(aminomethyl...)
Affinity DataIC50: 5nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
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TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436100(US10590077, Example 2 | 4-(((3S,4R)-1- ((2-chloro-...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
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TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436101(US10590077, Example 3 | 4-(((3S,4R)-1- ((5-chlorop...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436103(US10590077, Example 4 | 4-(((3S,4S)-1- ((2,4- dich...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent