Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 8658
TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411418(US10385036, Example 34 | N-(3-((3R,4R)-1-((R)-2-cy...)
Affinity DataIC50: 0.900nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411419(US10385036, Example 35 | N-(3-((3R,4R)-1-((R)-2-cy...)
Affinity DataIC50: 1nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411412(US10385036, Example 28 | (R)-2-fluoro-N-(1-methyl-...)
Affinity DataIC50: 1nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411417(US10385036, Example 33 | N-(3-((3R,4R)-1-((R)-2-cy...)
Affinity DataIC50: 1.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411410(US10385036, Example 26 | (R)-1,3,5-trimethyl-N-(1-...)
Affinity DataIC50: 1.30nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411411(US10385036, Example 27 | (R)-2-ethoxy-N-(1-methyl-...)
Affinity DataIC50: 1.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411409(US10385036, Example 25 | (R)-4-methyl-N-(1-methyl-...)
Affinity DataIC50: 2.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411415(US10385036, Example 31 | (R)-N-(3-(1-(2-(bicyclo[1...)
Affinity DataIC50: 2.40nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411416(US10385036, Example 32 | N-(3-((3R,4R)-1-((R)-2-cy...)
Affinity DataIC50: 2.5nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411400(US10385036, Example 16 | (S)-N-(3-(1-(2,3-dimethyl...)
Affinity DataIC50: 3.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411403(US10385036, Example 19 | (R)-N-(3-(1-(cyclopentane...)
Affinity DataIC50: 3.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411391(US10385036, Example 7 | (R)-N-(3-(1-(2-cyclopentyl...)
Affinity DataIC50: 4.5nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411389(US10385036, Example 5 | 4-fluoro-N-(3-((3R,4R)-1-i...)
Affinity DataIC50: 5.10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411387(US10385036, Example 3 | N-(3-((3R,4R)-1-(cyclopent...)
Affinity DataIC50: 5.30nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411398(US10385036, Example 14 | N-(3-(1-(cyclohexanecarbo...)
Affinity DataIC50: 5.60nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411394(US10385036, Example 10 | (R)-4-fiuoro-N-(1-methyl-...)
Affinity DataIC50: 5.60nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411408(US10385036, Example 24 | Preparation of (R)-4-fluo...)
Affinity DataIC50: 5.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411401(US10385036, Example 17 | N-(3-(1-(cyclopentanecarb...)
Affinity DataIC50: 5.90nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411399(US10385036, Example 15 | 4-fluoro-N-(3-(1-(2-fluor...)
Affinity DataIC50: 6.80nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411402(US10385036, Example 18 | (R)-4-fluoro-N-(3-(1-isob...)
Affinity DataIC50: 7nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411396(US10385036, Example 12 | 4-Fluoro-N-(1-methyl-3-(1...)
Affinity DataIC50: 7.80nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411385(US10385036, Example 1 | Preparation of 4-fluoro-N-...)
Affinity DataIC50: 8.20nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411413(US10385036, Example 29 | (R)-N-(1-methyl-3-(1-(2,3...)
Affinity DataIC50: 8.70nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411405(US10385036, Example 21 | Preparation of N-(3-((2S,...)
Affinity DataIC50: 9nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411414(US10385036, Example 30 | (R)-3,5-dimethyl-N-(1-met...)
Affinity DataIC50: 10nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411406(US10385036, Example 22 | Preparation of 4-fluoro-N...)
Affinity DataIC50: 10.6nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411386(US10385036, Example 2 | Preparation of N-(3-((3R,4...)
Affinity DataIC50: 11.4nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411393(US10385036, Example 9 | 4-fluoro-N-(1-methyl-3-(1-...)
Affinity DataIC50: 14.8nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411397(US10385036, Example 13 | N-(3-(1-(2-Cyclopropylace...)
Affinity DataIC50: 16.9nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411392(US10385036, Example 8 | N-(3-(1-(cyclopropanecarbo...)
Affinity DataIC50: 17.1nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411407(US10385036, Example 23 | Preparation of 4-fluoro-3...)
Affinity DataIC50: 19.9nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411395(US10385036, Example 11 | N-(3-(1-(cyclobutanecarbo...)
Affinity DataIC50: 28.8nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411388(US10385036, Example 4 | N-(3-((3S,4S)-1-(cyclopent...)
Affinity DataIC50: 33.8nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411390(US10385036, Example 6 | Preparation of 4-fluoro-N-...)
Affinity DataIC50: 75.9nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandPNGBDBM411404(US10385036, Example 20 | Preparation of N-(3-((2S,...)
Affinity DataIC50: 91.3nMAssay Description:In general, the assay is based on the interaction between N-terminally Six-Histidine-tagged-RORC2 ligand binding domain (6-His-RORC2 LBD), expressed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2020
Entry Details
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