Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 8621
TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408656(US10376504, Example 1-7)
Affinity DataKi:  7.5nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408657(US10376504, Example 1-8 | 4-(azepan-1-yl)-2- oxo-1...)
Affinity DataKi:  18nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408660(US10376504, Example 1-11 | 4-(4,4- dimethylpiperid...)
Affinity DataKi:  26.3nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408662(US10376504, Example 1-12 | 4-((2-(oxetan-3- yl)eth...)
Affinity DataKi:  71.1nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
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TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408659(US10376504, Example 1-10 | 4-(diethylamino)-2- oxo...)
Affinity DataKi:  88.9nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM408658(US10376504, Example 1-9 | 4-(azetidin-1-yl)-2- oxo...)
Affinity DataKi:  5.55E+3nMAssay Description:Rhesus PDE9A2 was amplified from rhesus whole brain cDNA (Biochain Institute) essentially as described in Hutson, et al. Neuropharmacology (2011) 61(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent