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Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 8623
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 28nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 40nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664(US10364234, Example 2 | (R)-5-cyano-4-ethoxy-N-(1-...)
Affinity DataIC50: 89nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 192nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663(US10364234, Example 1 | US10759788, Example 1 | (R...)
Affinity DataIC50: 4.37E+4nMAssay Description:The method described hereafter is used for determining the inhibitory activity of the present compounds on hERG1. Materials and Instruments(1) FluxOR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
Go to US Patent