Compile Data Set for Download or QSAR
Report error Found 183 Enz. Inhib. hit(s) with all data for entry = 2884
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384120(US10280171, Example 6 | 1-(3-(2,3- Dichlorophenyl)...)
Affinity DataIC50: 2nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384191(US10280171, Example 111 | (R)-8-(3-(3-Chloro-2-(me...)
Affinity DataIC50: 20nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384163(US10280171, Example 50 | (R)-8-(3-(2-chloro-3- met...)
Affinity DataIC50: 34nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384177(US10280171, Example 64A | 8-(3-(2,3-Dichlorophenyl...)
Affinity DataIC50: 34nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384208(US10280171, Example 131 | (1R)-8-[3-(3-amino- 2-ch...)
Affinity DataIC50: 35nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384163(US10280171, Example 50 | (R)-8-(3-(2-chloro-3- met...)
Affinity DataIC50: 39nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384152(US10280171, Example 38 | (S)-8-(3-(2,3-Dichlorophe...)
Affinity DataIC50: 40nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384191(US10280171, Example 111 | (R)-8-(3-(3-Chloro-2-(me...)
Affinity DataIC50: 43nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384139(US10280171, Example 25 | (1-(3-(3-Chloro-2-fluorop...)
Affinity DataIC50: 47nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384184(US10280171, Example 104 | 4-(6-(4-(Aminomethyl)-4-...)
Affinity DataIC50: 47nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384170(US10280171, Example 57 | (4-Amino-1-(3-(2,3-dichlo...)
Affinity DataIC50: 53nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384141(US10280171, Example 27 | (1-(3-(2-chloro-3- methox...)
Affinity DataIC50: 55nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384192(US10280171, Example 112 | 4-(6-(4-Amino-4-methylpi...)
Affinity DataIC50: 58nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384162(US10280171, Example 49 | (R)-8-(3-(3-chloro-2- flu...)
Affinity DataIC50: 62nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384156(US10280171, Example 42 | (S)-8-(3-(2-chloro-3- flu...)
Affinity DataIC50: 63nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384209(US10280171, Example 132 | 3-{6-[4-(amino- methyl)-...)
Affinity DataIC50: 63nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384167(US10280171, Example 54 | (R)-8-(3-(2- chlorophenyl...)
Affinity DataIC50: 64nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384207(US10280171, Example 130 | (1R)-8-[3-(2-amino- 3-ch...)
Affinity DataIC50: 65nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384178(US10280171, Example 64B)
Affinity DataIC50: 70nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384147(US10280171, Example 33 | (1-(3-(4-Chloro-3-methoxy...)
Affinity DataIC50: 72nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384152(US10280171, Example 38 | (S)-8-(3-(2,3-Dichlorophe...)
Affinity DataIC50: 75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384206(US10280171, Example 126 | (2S,4R)-4-Amino-8-(3-(2-...)
Affinity DataIC50: 75nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384121(US10280171, Example 7 | 3-(2,3-dichloro- phenyl)-6...)
Affinity DataIC50: 79nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384141(US10280171, Example 27 | (1-(3-(2-chloro-3- methox...)
Affinity DataIC50: 80nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384131(US10280171, Example 17 | (R)-8-(3-(4-chloro- pheny...)
Affinity DataIC50: 82nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384207(US10280171, Example 130 | (1R)-8-[3-(2-amino- 3-ch...)
Affinity DataIC50: 83nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384208(US10280171, Example 131 | (1R)-8-[3-(3-amino- 2-ch...)
Affinity DataIC50: 84nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384122(US10280171, Example 8 | 4-(aminomethyl)-1- (3-(2,3...)
Affinity DataIC50: 86nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384143(US10280171, Example 29 | (1-(3-(2-chloro- phenyl)-...)
Affinity DataIC50: 87nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384179(US10280171, Example 65B | 8-(3-(2,3-Dichlorophenyl...)
Affinity DataIC50: 93nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384147(US10280171, Example 33 | (1-(3-(4-Chloro-3-methoxy...)
Affinity DataIC50: 96nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384177(US10280171, Example 64A | 8-(3-(2,3-Dichlorophenyl...)
Affinity DataIC50: 98nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384184(US10280171, Example 104 | 4-(6-(4-(Aminomethyl)-4-...)
Affinity DataIC50: 99nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384193(US10280171, Example 113a | (R)-N-(1-(1-(6-chloro-5...)
Affinity DataIC50: 100nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384139(US10280171, Example 25 | (1-(3-(3-Chloro-2-fluorop...)
Affinity DataIC50: 101nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384148(US10280171, Example 34 | (R)-8-(3-(4-chloro-3- met...)
Affinity DataIC50: 102nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384129(US10280171, Example 15 | 1-(3-(4-Chlorophenyl)-1H-...)
Affinity DataIC50: 103nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384153(US10280171, Example 39 | (S)-8-(3-(2-chloro- pheny...)
Affinity DataIC50: 103nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384170(US10280171, Example 57 | (4-Amino-1-(3-(2,3-dichlo...)
Affinity DataIC50: 104nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384171(US10280171, Example 58 | 1-(3-(2,3-dichlo- ropheny...)
Affinity DataIC50: 109nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384117(US10280171, Example 1 | 1-(3-(2,3-dichlorophenyl)-...)
Affinity DataIC50: 110nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384131(US10280171, Example 17 | (R)-8-(3-(4-chloro- pheny...)
Affinity DataIC50: 118nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384167(US10280171, Example 54 | (R)-8-(3-(2- chlorophenyl...)
Affinity DataIC50: 119nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384209(US10280171, Example 132 | 3-{6-[4-(amino- methyl)-...)
Affinity DataIC50: 119nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384185(US10280171, Example 105 | 1-(3-(3-amino-2-chloroph...)
Affinity DataIC50: 120nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
The University of Texas System

US Patent
LigandPNGBDBM384212(US10280171, Example 135 | 4-[6-(4-amino-4- ethylpi...)
Affinity DataIC50: 122nMAssay Description:KYSE-520 cells (10 k cells/well) were grown in 384-well plate in 20 uL of medium (RPMI-1640, without phenol red, containing 10% FBS) at 37° C. with 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384192(US10280171, Example 112 | 4-(6-(4-Amino-4-methylpi...)
Affinity DataIC50: 128nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384196(US10280171, Example 116 | (S)-8-(3-(2-Amino-3-chlo...)
Affinity DataIC50: 132nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384129(US10280171, Example 15 | 1-(3-(4-Chlorophenyl)-1H-...)
Affinity DataIC50: 140nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
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Date in BDB:
2/24/2020
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Human)
The University of Texas System

US Patent
LigandPNGBDBM384132(US10280171, Example 18 | 1-(3-(3,4-dichloro- pheny...)
Affinity DataIC50: 141nMAssay Description:Recombinant full-length wild-type and E76K mutant human PTPN11 proteins were cloned, expressed (E. coli system), and isolated via a two-step purifica...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
Go to US Patent

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