Compile Data Set for Download or QSAR
Report error Found 65 Enz. Inhib. hit(s) with all data for entry = 2308
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361384(3-ethyl-N-(1H- pyrazolo[3,4-b] pyridin-3-yl)isothi...)
Affinity DataEC50:  100nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
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Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361392(3-((4,4-difluoropiperidin- 1-yl)methyl)-N- (1H-pyr...)
Affinity DataEC50:  81.1nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361391(3-(piperidin-1- ylmethyl)-N-(1H- pyrazolo[3,4-b]py...)
Affinity DataEC50:  1.56E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361390(3-methyl-N-(1H-pyrazolo [3,4-b]pyridin-3- yl)isoth...)
Affinity DataEC50:  180nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361389((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) isothi...)
Affinity DataEC50:  1.07E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361388(N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-3- (thiophen-3...)
Affinity DataEC50:  144nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361387(N-(1H-pyrazolo[4,3-b] pyiridn-3-yl)-3- (thiophen-3...)
Affinity DataEC50:  216nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361386(3-phenyl-N-(1H-pyrazolo [3,4-b]pyridin-3- yl)benzo...)
Affinity DataEC50:  2.04E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361385(3-phenyl-N-(1H-pyrazolo [4,3-b]pyridin-3- yl)benzo...)
Affinity DataEC50:  226nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361393(3-((4-fluoropiperidin- 1-yl)methyl)-N-(1H- pyrazol...)
Affinity DataEC50:  247nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361383(3-ethyl-N-(1H- pyrazolo[4,3-b] pyridin-3- yl)isoth...)
Affinity DataEC50:  38.3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361382(3-(sec-butyl)-N-(1H- pyrazolo[4,3-b]pyridin- 3-yl)...)
Affinity DataEC50:  54.2nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361381(3-methyl-N-(1H-pyrazolo [4,3-b]pyridin-3- yl)isoth...)
Affinity DataEC50:  157nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361380(2-(6-((1H-pyrazolo [4,3-b]pyridin- 3-yl)amino)benz...)
Affinity DataEC50:  1.03E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361379(3-cyclopropyl-N- (1H-pyrazolo [3,4-b]pyrazin-3-yl)...)
Affinity DataEC50:  61.1nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361378(3-cyclopropyl-N- (1H-pyrazolo [4,3-b]pyridin-3-yl)...)
Affinity DataEC50:  78.2nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361377(1-(4-(6-((1H- pyrazolo[4,3-b] pyridin-3-yl)amino) ...)
Affinity DataEC50:  199nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361376((6-((1H-pyrazolo[3,4-b] pyrazin-3- yl)amino)benzo[...)
Affinity DataEC50:  827nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361394(3-(((3,3-difluoro- cyclobutyl) (methyl)amino)methy...)
Affinity DataEC50:  334nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361395(3-(((3,3-difluorocyclobutyl) (methyl)amino)methyl)...)
Affinity DataEC50:  568nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361396(3-(morpholinomethyl)- N-(1H- pyrazolo[4,3-b]pyridi...)
Affinity DataEC50:  630nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361397(3-(morpholinomethyl)- N-(1H- pyrazolo[3,4-b]pyridi...)
Affinity DataEC50:  1.03E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361398(3-((4-(tert-butyl)piperidin- 1-yl)methyl)-N-(1H- p...)
Affinity DataEC50:  1.39E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361399(3-((4-(tert-butyl)piperidin- 1-yl)methyl)-N-(1H- p...)
Affinity DataEC50:  4.13E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361400(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-3- (pyrrolidin...)
Affinity DataEC50:  3.74E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361401((S)-3-((2- methylmorpholino) methyl)-N-(1H- pyrazo...)
Affinity DataEC50:  353nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361402(3-((2,2- dimethylmorpholino) methyl)-N- (1H-pyrazo...)
Affinity DataEC50:  147nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361403(3-((3,3-difluoropiperidin- 1-yl)methyl)-N-(1H- pyr...)
Affinity DataEC50:  55.9nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361404(3-((3,3-difluoropiperidin- 1-yl)methyl)-N-(1H- pyr...)
Affinity DataEC50:  101nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361405(1-(4-(6-((1H-pyrazolo [3,4-b]pyrazin-3-yl) amino)b...)
Affinity DataEC50:  154nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361406(1-(4-(6-((1H- pyrazolo[3,4-b] pyridin-3-yl) amino)...)
Affinity DataEC50:  409nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361407((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Affinity DataEC50:  388nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361408((4-(6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)ben...)
Affinity DataEC50:  1.20E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361360((6-((1H-pyrazolo[4,3-b] pyridin-3-yl) amino)benzo[...)
Affinity DataEC50:  607nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361345(3-neopentyl-N- (1H-pyrazolo[4,3- b]pyridin-3-yl)be...)
Affinity DataEC50:  284nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361346((6-((1H-pyrazolo [4,3-b]pyridin-3-yl)amino) benzo[...)
Affinity DataEC50:  325nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361347(6-((1H-pyrazolo[4,3-b] pyridin- 3-yl)amino)-N-(3,3...)
Affinity DataEC50:  32nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361348((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[...)
Affinity DataEC50:  60nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361349((6-((1H-pyrazolo [4,3-b]pyridin-3-yl) amino)benzo[...)
Affinity DataEC50:  303nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361350((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  306nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361351((6-((1H-pyrazolo [4,3-b]pyridin-3-yl) amino)benzo[...)
Affinity DataEC50:  136nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361352((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  233nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361353((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  1.34E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361354((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50: >1.00E+4nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361355((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  1.14E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361356((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  1.61E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361357((6-((1H-pyrazolo[4,3-b] pyridin-3-yl)amino) benzo[...)
Affinity DataEC50:  3.45E+3nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361358(6-((1H-pyrazolo[4,3-b] pyridin-3- yl)amino)-N-(3,3...)
Affinity DataEC50:  164nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361359((6-((1H-pyrazolo [4,3-b]pyridin-3- yl)amino)benzo[...)
Affinity DataEC50:  85nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM361344(3-methyl-N- (1H-pyrazolo[4,3-b] pyridin-3- yl)benz...)
Affinity DataEC50:  187nMAssay Description:In the first mode, a range of concentrations of the disclosed compounds are added to cells, followed by a single fixed concentration of agonist. If t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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