Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 2196
TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357272(US10214518, Compound 198 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataEC50:  2nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357269(US10214518, Compound 90 | 2-(((1s,4s)-4-((5- (ethy...)
Affinity DataEC50:  7nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(US10214518, Compound 184 | 2-(((1s,4s)-4-((5- (cya...)
Affinity DataEC50:  11nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetProstacyclin receptor(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(US10214518, Compound 111 | 2-(((1s,4s)-4-((5- (met...)
Affinity DataEC50:  16nMAssay Description:The HTRF assay was carried out using a two-step protocol essentially according to the kit manufacturer's instructions, in 20 μL total volume...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetMajor prion protein(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357271(US10214518, Compound 184 | 2-(((1s,4s)-4-((5- (cya...)
Affinity DataIC50: 20nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetMajor prion protein(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357270(US10214518, Compound 111 | 2-(((1s,4s)-4-((5- (met...)
Affinity DataIC50: 28nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetMajor prion protein(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357273(US10214518, Compound 146 | 2-(((1s,4s)-4-((5-(2- h...)
Affinity DataIC50: 70nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent

TargetMajor prion protein(Human)
Arena Pharmaceuticals

US Patent
LigandPNGBDBM357274(US10214518, Compound 135 | 2-(((1s,4s)-4-((4-(5- f...)
Affinity DataIC50: 220nMAssay Description:Blood collected from healthy human volunteers in aqueous trisodium citrate solution was centrifuged at 150 g for 15 min and the upper layer was recov...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent