Compile Data Set for Download or QSAR
Report error Found 81 Enz. Inhib. hit(s) with all data for entry = 1299
TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315338(US10172843, Example 72 | 3-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 24nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315341(US10172843, Example 75 | 1-Methyl-3-{1-[5- methyl-...)
Affinity DataIC50: 60nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315306(US10172843, Example 40 | 3-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 77nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315337(US10172843, Example 71 | 3-{1-[1,5-Dimethyl-2-(4- ...)
Affinity DataIC50: 84nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315340(US10172843, Example 74 | 3-{1-[2-(4- Methanesulfon...)
Affinity DataIC50: 94nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315346(US10172843, Example 80 | 3-{1-[5-Methyl-2-(4- phen...)
Affinity DataIC50: 99nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315311(US10172843, Example 46 | 3-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 110nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315299(US10172843, Example 33 | (6-Chloro-3-{1-[5- methyl...)
Affinity DataIC50: 130nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315320(US10172843, Example 54 | 1-(2-Methoxy-ethyl)-3- {1...)
Affinity DataIC50: 135nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315313(US10172843, Example 47 | 3-{1-[2-(3-Fluoro-4- trif...)
Affinity DataIC50: 145nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315319(US10172843, Example 53 | 1-Methyl-3-{1-[5- methyl-...)
Affinity DataIC50: 145nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315292(US10172843, Example 26 | 5-Chloro-3-ethyl-1-{1- [5...)
Affinity DataIC50: 150nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315343(US10172843, Example 77 | 3-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 155nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315347(US10172843, Example 81 | 1-Methyl-3-{1-[5- methyl-...)
Affinity DataIC50: 170nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315339(US10172843, Example 73 | 1-{1-[2-(4- Methanesulfon...)
Affinity DataIC50: 175nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315291(US10172843, Example 25 | 7-Fluoro-3-{1-[5-methyl- ...)
Affinity DataIC50: 180nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315275(US10172843, Example 9 | l-{1-[5-Methyl-2-(4- trifl...)
Affinity DataIC50: 190nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315294(US10172843, Example 28 | 3-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 190nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315284(US10172843, Example 18 | 5-Chloro-3-methyl-1-{1- [...)
Affinity DataIC50: 195nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315283(US10172843, Example 17 | 6-Bromo-3-[1-[[2-[4- (tri...)
Affinity DataIC50: 195nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315293(US10172843, Example 27 | 5-Chloro-3-(2-methoxy- et...)
Affinity DataIC50: 220nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315322(US10172843, Example 56 | 3-{1-[5-Benzyl-2-(4- trif...)
Affinity DataIC50: 225nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315296(US10172843, Example 30 | 5-Chloro-3-(2-hydroxy-eth...)
Affinity DataIC50: 230nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315305(US10172843, Example 39 | 1-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 242nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315336(US10172843, Example 70 | 1-{1-[1,5-Dimethyl-2-(4- ...)
Affinity DataIC50: 245nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315273(US10172843, Example 7 | 5-Chloro-1-{1-[5- methyl-2...)
Affinity DataIC50: 245nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315301(US10172843, Example 35 | 5-Chloro-3-(2- methanesul...)
Affinity DataIC50: 257nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315266(US10172843, Example 1 | 1-Methyl-3-{1-[5-methyl-2-...)
Affinity DataIC50: 280nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315295(US10172843, Example 29 | Acetic acid 2-(6-chloro- ...)
Affinity DataIC50: 280nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315276(US10172843, Example 10 | 1-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 280nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315325(US10172843, Example 59 | 3-{1-[2-(2-Chloro-4- trif...)
Affinity DataIC50: 285nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315308(US10172843, Example 42 | 3-{1-[2-(3,4-Dichloro- ph...)
Affinity DataIC50: 287nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315328(US10172843, Example 62 | 3-{1-[5-Propyl-2-(4- trif...)
Affinity DataIC50: 300nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315311(US10172843, Example 46 | 3-{1-[2-(3-Chloro-4- trif...)
Affinity DataIC50: 305nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315297(US10172843, Example 31 | 2-(6-Chloro-3-{1-[5- meth...)
Affinity DataIC50: 310nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315342(US10172843, Example 76 | 3-{1-[1-(2-Methoxy- ethyl...)
Affinity DataIC50: 317nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315298(US10172843, Example 32 | 2-(6-Chloro-3-{1-[5- meth...)
Affinity DataIC50: 330nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315321(US10172843, Example 55 | 3-{1-[5-(2-Methoxy- ethyl...)
Affinity DataIC50: 350nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315310(US10172843, Example 44 | 1-{1-[2-(3-Fluoro-4- trif...)
Affinity DataIC50: 385nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315272(US10172843, Example 6 | 1-{1-[5-Methyl-2-(4- trifl...)
Affinity DataIC50: 420nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315309(US10172843, Example 43 | 5-Chloro-1-{1-[5- methyl-...)
Affinity DataIC50: 445nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315332(US10172843, Example 66 | 3-{1-[1-Methyl-5-(4- trif...)
Affinity DataIC50: 450nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315268(US10172843, Example 3 | 1-{1-[5-Methyl-2-(4- trifl...)
Affinity DataIC50: 450nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315314(US10172843, Example 48 | 3-{1-[2-(3,4-Dichloro- ph...)
Affinity DataIC50: 450nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315277(US10172843, Example 11 | 6-(4-Methyl-piperazin-1- ...)
Affinity DataIC50: 460nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315285(US10172843, Example 19 | 4-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 470nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315304(US10172843, Example 38 | 3-{1-[5-Methyl-2-(4- trif...)
Affinity DataIC50: 470nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315331(US10172843, Example 65 | 1-Methyl-3-{1-[2- methyl-...)
Affinity DataIC50: 585nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315278(US10172843, Example 12 | 5-(4-Bromophenyl)-3-[1-[[...)
Affinity DataIC50: 590nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315303(US10172843, Example 37 | 6-Fluoro-3-{1-[5-methyl- ...)
Affinity DataIC50: 595nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
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