Compile Data Set for Download or QSAR
Report error Found 783 Enz. Inhib. hit(s) with all data for entry = 875
LigandPNGBDBM247849(US9688672, Example 456 | US9434719, 456 | US101129...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM296116(US10112931, Example 467 | (R)-3-(2-(((S)-1-(5-(2-f...)
Affinity DataIC50: 2.29nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
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LigandPNGBDBM247707(US9688672, Example 309 | US9434719, 309 | US101129...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247707(US9688672, Example 309 | US9434719, 309 | US101129...)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247567(US9688672, Example 133 | US9434719, 133 | US101129...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247614(US9688672, Example 216 | US9434719, 216 as TFA sal...)
Affinity DataIC50: 4nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247707(US9688672, Example 309 | US9434719, 309 | US101129...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247707(US9688672, Example 309 | US9434719, 309 | US101129...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247494(US9434719, 28 | BDBM295678)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247525(US9688672, Example 63 | US9434719, 63 | US10112931...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247590(US9688672, Example 179 | US9434719, 179 | US101129...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247599(US9688672, Example 197 | US9434719, 197 | US101129...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247601(US9688672, Example 201 | US9434719, 201 | US101129...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247873(US9688672, Example 480 | US9434719, 480 | US101129...)
Affinity DataIC50: 5nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247580(US9688672, Example 159 | US9434719, 159 | US101129...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247785(US9688672, Example 388 | US9434719, 388 as TFA sal...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247567(US9688672, Example 133 | US9434719, 133 | US101129...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247590(US9688672, Example 179 | US9434719, 179 | US101129...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247760(US9688672, Example 363 | US9434719, 363 as TFA sal...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247782(US9688672, Example 385 | US9434719, 385 | US101129...)
Affinity DataIC50: 7nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247526(US9688672, Example 64 | US9434719, 64 | US10112931...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247602(US9688672, Example 203 | US9434719, 203 | US101129...)
Affinity DataIC50: 8nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM296116(US10112931, Example 467 | (R)-3-(2-(((S)-1-(5-(2-f...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247624(US9688672, Example 226 | US9434719, 226 as TFA sal...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247701(US9688672, Example 303 | US9434719, 303 | US101129...)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247760(US9688672, Example 363 | US9434719, 363 as TFA sal...)
Affinity DataIC50: 9nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247496(US9688672, Example 33 | US9434719, 32 | US9434719,...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247594(US9688672, Example 187 | US9434719, 187 | US101129...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247597(US9434719, 193 | US10112931, Example 193)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247698(US9688672, Example 300 | US9434719, 300 | US101129...)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247856(US9688672, Example 463 | US9434719, 463 | US101129...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247568(US9688672, Example 135 | US9434719, 135 | US101129...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247605(US9688672, Example 207 | US9434719, 207 as TFA sal...)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM175219(US9688672, Example 213 | US10112931, Example 213)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247614(US9688672, Example 216 | US9434719, 216 as TFA sal...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247859(US9688672, Example 466 | US9434719, 466 | US101129...)
Affinity DataIC50: 11nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM174784(US9688672, Example 85 | US10112931, Example 85)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247570(US9688672, Example 139 | US9434719, 139 | US101129...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247576(US9434719, 151 | US10112931, Example 151)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247615(US9688672, Example 217 | US9434719, 217 as TFA sal...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247636(US9688672, Example 238 | US9434719, 238 as TFA sal...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247869(US9688672, Example 476 | US9434719, 476 as TFA sal...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247863(US9434719, 470 | US10112931, Example 470)
Affinity DataIC50: 12.8nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247513(US9688672, Example 51 | US9434719, 51 | US10112931...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM174784(US9688672, Example 85 | US10112931, Example 85)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM174788(US9688672, Example 91 | US10112931, Example 91)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
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Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247635(US9688672, Example 237 | US9434719, 237 as TFA sal...)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247955(US9434719, 321 as TFA salt | US10112931, Example 3...)
Affinity DataIC50: 13nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247596(US9688672, Example 191 | US9434719, 191 | US101129...)
Affinity DataIC50: 14nMpH: 7.4 T: 2°CAssay Description:Mutant IDH1 R132H catalytic activity was monitored using the quantitative liquid chromatography/mass spectrometry (LC-MS) detection of 2-HG, a produc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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LigandPNGBDBM247617(US9688672, Example 219 | US9434719, 219 as TFA sal...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The IDH1 (R132H) mutant catalyzes the reduced form of NADP+ (NADPH) and α-ketoglutarate (α-KG) to form nicotinamide adenine dinucleotide ph...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
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