Compile Data Set for Download or QSAR
Report error Found 125 Enz. Inhib. hit(s) with all data for entry = 728
TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288255(US10087185, Example 73 | 7-Chloro-5-(2-isopropyl-6...)
Affinity DataIC50: 0.0100nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288248(US10087185, Example 66 | 5-(2,6-Bis(trifluoromethy...)
Affinity DataIC50: 0.0130nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288254(US10087185, Example 72 | 5-(2-Isopropyl-6-(trifluo...)
Affinity DataIC50: 0.0130nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288245(US10087185, Example 63 | 5-(2,6-Bis(trifluoromethy...)
Affinity DataIC50: 0.0160nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288246(US10087185, Example 64 | 5-(2,6-Bis(trifluoromethy...)
Affinity DataIC50: 0.0160nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288247(US10087185, Example 65 | 5-(2,6-Bis(trifluoromethy...)
Affinity DataIC50: 0.0160nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288253(US10087185, Example 71 | 5-(2-Isopropyl-6-(trifluo...)
Affinity DataIC50: 0.0160nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288302(US10087185, Example 120 | 7-(7-Chloro-1H-indazol-5...)
Affinity DataIC50: 0.0160nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288250(US10087185, Example 68 | 5-(2-Cyclopropyl-6-(trifl...)
Affinity DataIC50: 0.0200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288303(US10087185, Example 121 | 6-(Difluoromethyl)-7-(7-...)
Affinity DataIC50: 0.0250nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288237(US10087185, Example 55 | 6-(4-Fluorophenyl)-5-(7-m...)
Affinity DataIC50: 0.0400nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288235(US10087185, Example 53 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.0500nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288249(US10087185, Example 67 | 5-(2-Cyclopropyl-6-(trifl...)
Affinity DataIC50: 0.0500nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288251(US10087185, Example 69 | 5-(2-Cyclopropyl-6-(trifl...)
Affinity DataIC50: 0.0500nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288301(US10087185, Example 119 | 5-[6-(Difluoromethyl)-2-...)
Affinity DataIC50: 0.0500nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288304(US10087185, Example 122 | 5-[6-(Difluoromethyl)-4-...)
Affinity DataIC50: 0.0500nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288189(US10087185, Example 7 | 5-(7-Chloro-1H-indazol-5-y...)
Affinity DataIC50: 0.0630nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288239(US10087185, Example 57 | 5-(6-(4-Fluorophenyl)-2-(...)
Affinity DataIC50: 0.0630nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288252(US10087185, Example 70 | 7-Chloro-5-(2-cyclopropyl...)
Affinity DataIC50: 0.0630nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288252(US10087185, Example 70 | 7-Chloro-5-(2-cyclopropyl...)
Affinity DataIC50: 0.0630nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288183(US10087185, Example 1 | 5-(7-Chloro-1H-indazol-5-y...)
Affinity DataIC50: 0.0790nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288218(US10087185, Example 36 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.0790nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288256(US10087185, Example 74 | 5-(2-Isopropyl-6-(trifluo...)
Affinity DataIC50: 0.0790nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288198(US10087185, Example 16 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288224(US10087185, Example 42 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288294(US10087185, Example 112 | 5-(7-Chloro-1H-indazol-5...)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288307(US10087185, Example 125 | 7-(7-Chloro-1H-indazol-5...)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288220(US10087185, Example 38 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288244(US10087185, Example 62 | 2-Cyclopropyl-6-(4-fluoro...)
Affinity DataIC50: 0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288257(US10087185, Example 75 | 7-Chloro-5-(2-cyclopropyl...)
Affinity DataIC50: 0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288260(US10087185, Example 78 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288305(US10087185, Example 123 | 6-(Difluoromethyl)-4-met...)
Affinity DataIC50: 0.126nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288193(US10087185, Example 11 | 2-(Difluoromethyl)-6-(tri...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288199(US10087185, Example 17 | 6-(Difluoromethyl)-5-(7-m...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288258(US10087185, Example 76 | 2-Cyclopropyl-8-methyl-5-...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288262(US10087185, Example 80 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288275(US10087185, Example 93 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288285(US10087185, Example 103 | 7-Chloro-5-(2-ethyl-8-me...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288286(US10087185, Example 104 | 7-Ethyl-5-(8-methyl-2,6-...)
Affinity DataIC50: 0.158nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288184(US10087185, Example 2 | 5-(7-Methyl-1H-indazol-5-y...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288188(US10087185, Example 6 | 5-(7-Chloro-1H-indazol-5-y...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288215(US10087185, Example 33 | 2-Cyclopropyl-8-fluoro-5-...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288230(US10087185, Example 48 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288243(US10087185, Example 61 | 2-Ethyl-6-(4-fluorophenyl...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288265(US10087185, Example 83 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288185(US10087185, Example 3 | 5-(2,6-Bis(trifluoromethyl...)
Affinity DataIC50: 0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288200(US10087185, Example 18 | 7-Chloro-5-(6-(difluorome...)
Affinity DataIC50: 0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288259(US10087185, Example 77 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288281(US10087185, Example 99 | 5-(2-Cyclopropyl-8-methyl...)
Affinity DataIC50: 0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
Go to US Patent

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288259(US10087185, Example 77 | 5-(7-Chloro-1H-indazol-5-...)
Affinity DataIC50: 0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
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