Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 669
TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 2.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286098(US10081635, Example 41 | (R)-3-((7-(methyl(7H-pyrr...)
Affinity DataIC50: 5.80nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 8.5nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286098(US10081635, Example 41 | (R)-3-((7-(methyl(7H-pyrr...)
Affinity DataIC50: 24.7nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 29.3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 40.4nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286098(US10081635, Example 41 | (R)-3-((7-(methyl(7H-pyrr...)
Affinity DataIC50: 58.6nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286098(US10081635, Example 41 | (R)-3-((7-(methyl(7H-pyrr...)
Affinity DataIC50: 110nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 148nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 198nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 252nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 412nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 422nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286096(US10081635, Example 55 | 3-(7-(methyl(7H-pyrrolo[2...)
Affinity DataIC50: 694nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286097(US10081635, Example 66 | (S)-3-(7-(methyl(7H-pyrro...)
Affinity DataIC50: 787nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286097(US10081635, Example 66 | (S)-3-(7-(methyl(7H-pyrro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286097(US10081635, Example 66 | (S)-3-(7-(methyl(7H-pyrro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286097(US10081635, Example 66 | (S)-3-(7-(methyl(7H-pyrro...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286099(US10081635, Example 62 | N-(5-(ethylsulfonyl)-5-az...)
Affinity DataIC50: 1.00E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Yang Ji Chemical

US Patent
LigandPNGBDBM286095(US10081635, Example 5 | (R)-3-(7-(methyl(7H-pyrrol...)
Affinity DataIC50: 1.09E+3nMAssay Description:Kinases used were human-derived JAK1, JAK2, JAK3, and TYK2 (Millipore, Germany). Each of these kinases was diluted with a suitable buffer solution as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/13/2019
Entry Details
Go to US Patent