Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 4187
TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM403740(6-Chloro-7-((3-(cyclopropylmethyl)-7-methyl-3H-imi...)
Affinity DataKi:  0.900nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400239(7-((1-(2-Cyclopropylethyl)-5-fluoro-1H-benzo[d]imi...)
Affinity DataKi:  4.10nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400243(6-((3-(Cyclopropylmethyl)-7-methyl-3H-imidazo[4,5-...)
Affinity DataKi:  6.40nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400238(7-((1-((3,3-Difluorocyclobutyl)methyl)-5-fluoro-1H...)
Affinity DataKi:  6.70nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400240(7-((1-(Cyclopropylmethyl)-5-fluoro-4-methyl-1H-ben...)
Affinity DataKi:  11.8nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400242(N-(6-(1H-Imidazol-1-yl)pyridin-3-yl)-3-(cyclopropy...)
Affinity DataKi:  18.4nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400234(7-((1-(Cyclopropylmethyl)-1H-imidazo[4,5-b]pyrazin...)
Affinity DataKi:  24nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400241(7-((3-(Cyclopropylmethyl)-3H-imidazo[4,5-b]pyridin...)
Affinity DataKi:  34.6nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400236(7-((9-(Cyclopropylmethyl)-9H-purin-2-yl)amino)-4-(...)
Affinity DataKi:  38nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400233(4-Cyclopropyl-7-((1-(cyclopropylmethyl)-1H-imidazo...)
Affinity DataKi:  38.8nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-5(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM400235(6-((1-(Cyclopropylmethyl)-1H-imidazo[4,5-b]pyrazin...)
Affinity DataKi:  42nMAssay Description:The GABAAα5/β3/γ2 protein used for the Scintillation Proximity Assay was derived from membranes produced from HEK293 GABAA α5/ ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details
Go to US Patent