Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50034935
TargetSerine protease 1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070501({(R)-1-Benzyl-2-[(R)-2-((S)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070501({(R)-1-Benzyl-2-[(R)-2-((S)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 9nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070499((R)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-carboxy-p...)
Affinity DataIC50: 22.3nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366497(CHEMBL1790164)
Affinity DataIC50: 70nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070495([(S)-1-((S)-1-Formyl-4-guanidino-butylcarbamoyl)-2...)
Affinity DataIC50: 130nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070502(((R)-1-Benzyl-2-{(R)-2-[(S)-4-guanidino-1-(2-oxo-e...)
Affinity DataIC50: 190nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-3(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070499((R)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-carboxy-p...)
Affinity DataIC50: 438nMAssay Description:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070502(((R)-1-Benzyl-2-{(R)-2-[(S)-4-guanidino-1-(2-oxo-e...)
Affinity DataIC50: 1.76E+3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070494({(R)-1-Benzyl-2-[(R)-2-((R)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 1.79E+3nMAssay Description:Ability to inhibit Trypsin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50: 2.00E+3nMAssay Description:Ability to inhibit IL-1 beta converting enzyme was evaluated in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070496((R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataIC50: 2.90E+3nMAssay Description:Ability to inhibit IL-1 beta converting enzyme was evaluated in LPS-stimulated human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070494({(R)-1-Benzyl-2-[(R)-2-((R)-1-formyl-4-guanidino-b...)
Affinity DataIC50: 5.44E+3nMAssay Description:Ability to inhibit Thrombin was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366496(CHEMBL1790166)
Affinity DataIC50: 8.50E+3nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070503([(S)-1-((R)-1-Formyl-4-guanidino-butylcarbamoyl)-2...)
Affinity DataIC50: 1.25E+4nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50366498(CHEMBL1790165)
Affinity DataIC50: 6.50E+4nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50: 6.80E+4nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50: 7.00E+4nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPapain(Papaya)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070497({(S)-1-[(S)-4-Guanidino-1-(2-oxo-ethyl)-butylcarba...)
Affinity DataIC50: 1.05E+5nMAssay Description:Ability to inhibit papain was evaluated by amidolytic method using fluorogenic or chromogenic substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-1(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM50070496((R)-3-((S)-2-{(S)-2-[(S)-2-Acetylamino-3-(4-hydrox...)
Affinity DataIC50: 1.42E+5nMAssay Description:Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCaspase-3(Human)
Institute For Drug Research

Curated by ChEMBL
LigandPNGBDBM10355(CHEMBL37630 | (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-aceta...)
Affinity DataIC50: 1.90E+5nMAssay Description:Amidolytic activity of THP.1 cell lysate against Caspase-3 using C3-Asp-AMC as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed