Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50036715
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  53nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(H132A) human P2Y1 receptor in presence of MRS2179 (P<0.005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  27nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(F226A) human P2Y1 receptor in presence of MRS2179.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  738nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(H277A) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  36nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(Y136A) human P2Y1 receptor in presence of MRS2179 (P<0.005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  11nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  20nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(F226A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  19nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  324nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(R310K) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  13nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor in presence of MRS2179 (P<0.005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  31nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  18nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(H132A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  115nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(H277A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  2.27E+3nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(R310K) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  1.58E+3nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(K280A) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  103nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(F131A) human P2Y1 receptor in presence of MRS2179 (P<0.05)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  12nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(Y136A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  12nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  1.90nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(S317A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  323nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(Q307A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  1.52E+3nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(K280A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  1.90nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(WT) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  12nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(T221A) human P2Y1 receptor in presence of MRS2179 (P<0.005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  10nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(S314T) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  378nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(Q307A) human P2Y1 receptor in presence of MRS2179More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  2.5nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(T221A) human P2Y1 receptor.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2Y purinoceptor 1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50118242([({[(2R,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H...)
Affinity DataEC50:  25nMAssay Description:Compound was measured for the antagonism of the activation of phospholipase C in mutant(T222A) human P2Y1 receptor in presence of MRS2179 (P<0.005)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)