Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 351
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM874(benzyl N-[(1S)-1-{[(2S,3S,4R)-4-{[(1R)-1-[(1H-1,3-...)
Affinity DataKi:  3.40nM ΔG°:  -50.3kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM856(benzyl N-[(1S)-1-{[(1S,2S)-1-[(9R,12R)-8,11-dioxo-...)
Affinity DataKi:  6.60nM ΔG°:  -48.6kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM858(benzyl N-[(1S)-1-{[(1S,2S)-1-[(13R,16R)-12,15-diox...)
Affinity DataKi:  6.90nM ΔG°:  -48.5kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM859(benzyl N-[(1S)-1-{[(1S,2S)-1-[(16R,19R)-15,18-diox...)
Affinity DataKi:  7.5nM ΔG°:  -48.2kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM865(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  7.60nM ΔG°:  -48.2kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM866(benzyl N-[(1S)-1-{[(1S,2S)-1-[(13R,16R)-12,15-diox...)
Affinity DataKi:  7.70nM ΔG°:  -48.2kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM857(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  7.90nM ΔG°:  -48.1kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM870(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  8nM ΔG°:  -48.1kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM872((3R)-oxolan-3-yl N-[(1S,2S)-1-[(10R,13R)-9,12-diox...)
Affinity DataKi:  8.20nM ΔG°:  -48.0kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM864(benzyl N-[(1S)-1-{[(1S,2S)-1-[(9R,12R)-8,11-dioxo-...)
Affinity DataKi:  9.40nM ΔG°:  -47.7kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM875(benzyl N-[(1S)-1-{[(2S,3S,4R)-3-hydroxy-4-{[(1S,2S...)
Affinity DataKi:  9.5nM ΔG°:  -47.6kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM871((2S)-N-[(1S,2S)-1-[(10R,13R)-9,12-dioxo-10-(propan...)
Affinity DataKi:  11.1nM ΔG°:  -47.2kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM862(tert-butyl N-[(1S,2S)-1-[(13R,16R)-12,15-dioxo-13-...)
Affinity DataKi:  12.6nM ΔG°:  -46.9kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM873((3R)-oxolan-3-yl N-[(1S,2S)-1-[(13R,16R)-12,15-dio...)
Affinity DataKi:  13.8nM ΔG°:  -46.7kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM861(tert-butyl N-[(1S,2S)-1-[(10R,13R)-9,12-dioxo-10-(...)
Affinity DataKi:  14nM ΔG°:  -46.6kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Sandoz Research Institute

LigandPNGBDBM870(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  16nM ΔG°:  -46.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM867(tert-butyl N-[(1S,2S)-1-[(9R,12R)-8,11-dioxo-9-(pr...)
Affinity DataKi:  16.1nM ΔG°:  -46.3kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM860(tert-butyl N-[(1S,2S)-1-[(9R,12R)-8,11-dioxo-9-(pr...)
Affinity DataKi:  17nM ΔG°:  -46.1kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Sandoz Research Institute

LigandPNGBDBM857(benzyl N-[(1S)-1-{[(1S,2S)-1-[(10R,13R)-9,12-dioxo...)
Affinity DataKi:  19nM ΔG°:  -45.8kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM863(tert-butyl N-[(1S,2S)-1-[(16R,19R)-15,18-dioxo-16-...)
Affinity DataKi:  23.2nM ΔG°:  -45.3kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Sandoz Research Institute

LigandPNGBDBM858(benzyl N-[(1S)-1-{[(1S,2S)-1-[(13R,16R)-12,15-diox...)
Affinity DataKi:  27nM ΔG°:  -44.9kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Sandoz Research Institute

LigandPNGBDBM875(benzyl N-[(1S)-1-{[(2S,3S,4R)-3-hydroxy-4-{[(1S,2S...)
Affinity DataKi:  50nM ΔG°:  -43.3kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM868(tert-butyl N-[(1S,2S)-1-[(10R,13R)-9,12-dioxo-10-(...)
Affinity DataKi:  68.8nM ΔG°:  -42.5kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus 2)
Sandoz Research Institute

LigandPNGBDBM874(benzyl N-[(1S)-1-{[(2S,3S,4R)-4-{[(1R)-1-[(1H-1,3-...)
Affinity DataKi:  120nM ΔG°:  -41.1kJ/molepH: 4.7 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Sandoz Research Institute

LigandPNGBDBM869(tert-butyl N-[(1S,2S)-1-[(13R,16R)-12,15-dioxo-13-...)
Affinity DataKi:  208nM ΔG°:  -39.7kJ/molepH: 6.25 T: 2°CAssay Description:Enzymatic activity was measured by following cleavage of the substrate H-Lys-Ala-Arg-Val-Leu-pNph-Glu-Ala-Nle-NH2. Products of the cleavage reaction ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2004
Entry Details Article
PubMed