Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50006042
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034435(BMS-182874 | 5-Dimethylamino-naphthalene-1-sulfoni...)
Affinity DataIC50: 150nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034435(BMS-182874 | 5-Dimethylamino-naphthalene-1-sulfoni...)
Affinity DataIC50: 570nMAssay Description:Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034452(CHEMBL453 | Gantrisin | Sosol | Sulfalar | Eryzole...)
Affinity DataIC50: 780nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034465(N-[5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphtha...)
Affinity DataIC50: 880nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034437(5-Dimethylaminomethyl-naphthalene-1-sulfonic acid ...)
Affinity DataIC50: 2.80E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034450(5-Amino-naphthalene-1-sulfonic acid (3,4-dimethyl-...)
Affinity DataIC50: 4.00E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034410(5-Isopropenyl-naphthalene-1-sulfonic acid (3,4-dim...)
Affinity DataIC50: 5.70E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034462(5-Methoxy-naphthalene-1-sulfonic acid (3,4-dimethy...)
Affinity DataIC50: 6.50E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034418(5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethy...)
Affinity DataIC50: 7.80E+3nMAssay Description:Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034461(N-(3,4-Dimethyl-isoxazol-5-yl)-4-hydroxy-benzenesu...)
Affinity DataIC50: 9.20E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034468(4-Benzylamino-N-(3,4-dimethyl-isoxazol-5-yl)-benze...)
Affinity DataIC50: 9.80E+3nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034441(5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphthalen...)
Affinity DataIC50: 1.30E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034446(Naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol...)
Affinity DataIC50: 2.00E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034440(N-(3,4-Dimethyl-isoxazol-5-yl)-4-propylamino-benze...)
Affinity DataIC50: 2.70E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034474(4-Amino-N-(3-methyl-isoxazol-5-yl)-benzenesulfonam...)
Affinity DataIC50: 2.80E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50044084(4-Cyano-N-(3,4-dimethyl-isoxazol-5-yl)-benzenesulf...)
Affinity DataIC50: 3.20E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50036288(4-Dimethylamino-N-(3,4-dimethyl-isoxazol-5-yl)-ben...)
Affinity DataIC50: 8.40E+4nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034435(BMS-182874 | 5-Dimethylamino-naphthalene-1-sulfoni...)
Affinity DataKi:  55nMAssay Description:Binding affinity towards ET1 receptor was determined in A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034435(BMS-182874 | 5-Dimethylamino-naphthalene-1-sulfoni...)
Affinity DataKi: >2.00E+5nMAssay Description:Selectivity for the ET-A receptor over ETB receptor was observed in rat cerebellar membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed