Compile Data Set for Download or QSAR
Report error Found 33 Enz. Inhib. hit(s) with all data for entry = 50003381
Target5-hydroxytryptamine receptor 1D(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  0.126nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against 5-hydroxytryptamine 1D receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469882(CHEMBL73446)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469879(CHEMBL72088)
Affinity DataKi:  3.20nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469881(CHEMBL311150)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469875(CHEMBL72981)
Affinity DataKi:  5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469876(CHEMBL306384)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469876(CHEMBL306384)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469881(CHEMBL311150)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1B receptor in rat striatal membrane with [125I]- iodocyanopindololMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469878(CHEMBL72700)
Affinity DataKi:  6.30nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50060518(3-(3-Dimethylamino-propyl)-4-methoxy-N-(4-pyridin-...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Guinea pig)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469877(CHEMBL72092)
Affinity DataKi:  32nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 1D receptor in guinea-pig striatum in presence of BMY-7378 and mesulergineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469881(CHEMBL311150)
Affinity DataKi:  251nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi:  316nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus with [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against alpha-2 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against alpha-1 adrenoceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+3nMAssay Description:Binding affinity against muscarinic M3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469876(CHEMBL306384)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469875(CHEMBL72981)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus with [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469878(CHEMBL72700)
Affinity DataKi:  5.01E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469880(CHEMBL75771)
Affinity DataKi:  6.31E+3nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine receptor D1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against dopamine D3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 4(Human)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity against 5-hydroxytryptamine 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Mouse)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM79215(SMR001230745 | N-[4-methoxy-3-(4-methylpiperazin-1...)
Affinity DataKi: <1.00E+4nMAssay Description:Tested for 5-hydroxytryptamine receptor uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50469877(CHEMBL72092)
Affinity DataKi: <1.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Glaxo Research and Development

Curated by ChEMBL
LigandPNGBDBM50060518(3-(3-Dimethylamino-propyl)-4-methoxy-N-(4-pyridin-...)
Affinity DataKi:  2.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hippocampus using [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed