Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50005359
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036033((2S)-2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-...)
Affinity DataIC50: 85nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036033((2S)-2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-...)
Affinity DataIC50: 97nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036031(2-[[N-[(N`-methylamino)carbonyl)-N-hydroxyamino]me...)
Affinity DataIC50: 98nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036028(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-7-(4-...)
Affinity DataIC50: 100nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036031(2-[[N-[(N`-methylamino)carbonyl)-N-hydroxyamino]me...)
Affinity DataIC50: 110nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036025(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-7-phe...)
Affinity DataIC50: 120nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036028(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-7-(4-...)
Affinity DataIC50: 120nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036025(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-7-phe...)
Affinity DataIC50: 140nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036035((2R)-2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-...)
Affinity DataIC50: 170nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036035((2R)-2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-...)
Affinity DataIC50: 180nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036026(2-[(N-hydroxyamino)methyl)-6-phenoxy-1,4-benzodiox...)
Affinity DataIC50: 390nMAssay Description:Ex vivo inhibition of 5-lipoxygenase was determined by the measurement of A-23187-stimulated LTB4 production in dog blood at 12 h, following intraven...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036032(2-[[N-[(N`-methylamino)carbonyl)-N-hydroxyamino]me...)
Affinity DataIC50: 420nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036026(2-[(N-hydroxyamino)methyl)-6-phenoxy-1,4-benzodiox...)
Affinity DataIC50: 450nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036032(2-[[N-[(N`-methylamino)carbonyl)-N-hydroxyamino]me...)
Affinity DataIC50: 480nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036034(2-[[N-[(N`-butylamino)carbonyl]-N-hydroxyamino]met...)
Affinity DataIC50: 1.20E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036034(2-[[N-[(N`-butylamino)carbonyl]-N-hydroxyamino]met...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541(Leutrol | CHEMBL93 | N-(1-Benzo(b)thien-2-ylethyl)...)
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50000541(Leutrol | CHEMBL93 | N-(1-Benzo(b)thien-2-ylethyl)...)
Affinity DataIC50: 2.20E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036029(2-[[N-[(N`-benzylamino)carbonyl]-N-hydroxyamino]me...)
Affinity DataIC50: 2.70E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036029(2-[[N-[(N`-benzylamino)carbonyl]-N-hydroxyamino]me...)
Affinity DataIC50: 2.90E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036030(2-[[N-[(N`-allylamino)carbonyl]-N-hydroxyamino]met...)
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036030(2-[[N-[(N`-allylamino)carbonyl]-N-hydroxyamino]met...)
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036027(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-1,4-b...)
Affinity DataIC50: 1.50E+4nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]AA to LTB4 in guinea pig peritoneal polymorphonuclear leuko...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50036027(2-[[N-(aminocarbonyl)-N-hydroxyamino]methyl]-1,4-b...)
Affinity DataIC50: 1.80E+4nMAssay Description:In vitro 5-lipoxygenase inhibitory activity against A-23187-stimulated conversion of [14C]-AA to 5-HETE in guinea pig peritoneal polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed