Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50022034
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataKd:  2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50647408(CHEMBL5590963)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50549954(CHEMBL4791380 | US11505536, Example 11)
Affinity DataIC50: 0.220nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581554(US11505536, Example 102 | (R)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 0.260nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50549951(CHEMBL4745588 | US11505536, Example 52)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581488(US11505536, Example 36 | 6-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581569(US11505536, Example 117 | 2-(2-Chlorophenyl)-6-(4-...)
Affinity DataIC50: 0.420nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581521(US11505536, Example 69 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581516(US11505536, Example 64 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581557(US11505536, Example 105 | 2-(2-(Difluoromethyl)phe...)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581519(US11505536, Example 67 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.610nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581513(US11505536, Example 61 | 2-(3-Chloro-2-methoxy-5-m...)
Affinity DataIC50: 0.620nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581555(US11505536, Example 103 | 6-(4-Ethyl-3-(hydroxymet...)
Affinity DataIC50: 0.670nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581547(US11505536, Example 95 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.770nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581487(US11505536, Example 35 | 6-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581553(US11505536, Example 101 | (S)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581541(US11505536, Example 89 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581529(US11505536, Example 77 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581526(US11505536, Example 74 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 2.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM581510(US11505536, Example 58 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 8.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataIC50: 1.40E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed