Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50020789
TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human sEH using fluorogenic PHOME as substrate measured after 10 sec by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633579BDBM50633579(CHEMBL5410625)
Affinity DataIC50: 13nMAssay Description:Inhibition of IDO1 in human HeLa cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 in human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 in MTAP knockout human HCT-116 cells assessed as reduction in kynurenine level incubated for 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 29nMAssay Description:Inhibition of IDO1 in HEK293T cells assessed as reduction in kynurenine level incubated for 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 40nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633587BDBM50633587(CHEMBL5433373)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633584BDBM50633584(CHEMBL5406987)
Affinity DataIC50: 50nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 68nMAssay Description:Inhibition of sEH in IFNgamma induced human HAP1 cells assessed as reduction in kynurenine productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633579BDBM50633579(CHEMBL5410625)
Affinity DataIC50: 90nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633586BDBM50633586(CHEMBL5414894)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633580BDBM50633580(CHEMBL5433736)
Affinity DataIC50: 100nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633590BDBM50633590(CHEMBL5409600)
Affinity DataIC50: 159nMAssay Description:Displacement of tracer from NanoLuc fused sEH in HEK293T cells assessed as decrease in BRET ratio incubated for 5 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633588BDBM50633588(CHEMBL5409480)
Affinity DataIC50: 400nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633598BDBM50633598(CHEMBL5429523)
Affinity DataIC50: 770nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633591BDBM50633591(CHEMBL5438896)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633593BDBM50633593(CHEMBL5414973)
Affinity DataIC50: 1.94E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633581BDBM50633581(CHEMBL5405903)
Affinity DataIC50: 3.01E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633585BDBM50633585(CHEMBL5404295)
Affinity DataIC50: 3.05E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633589BDBM50633589(CHEMBL5423633)
Affinity DataIC50: 3.49E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633583BDBM50633583(CHEMBL5429542)
Affinity DataIC50: 5.43E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633594BDBM50633594(CHEMBL5397941)
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633602BDBM50633602(CHEMBL5418628)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633592BDBM50633592(CHEMBL5440751)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633596BDBM50633596(CHEMBL5419808)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633597BDBM50633597(CHEMBL5420772)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633595BDBM50633595(CHEMBL1721305)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633600BDBM50633600(CHEMBL5397386)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633601BDBM50633601(CHEMBL5424504)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633582BDBM50633582(CHEMBL5400830)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Max Planck Institute of Molecular Physiology

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50633599BDBM50633599(CHEMBL5393864)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IDO1 in human BXPC-3 cells assessed as reduction in IFNgamma induced kynurenine level incubated for 48 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed