Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with all data for entry = 50020046
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM7918(PBD150 | 1-(3-(1H-Imidazol-1-yl)propyl)-3-(3,4-dim...)
Affinity DataIC50: 640nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-AMC as substrate incubated for 60...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM50625804(CHEMBL5435101)
Affinity DataIC50: 4.34E+3nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-AMC as substrate incubated for 60...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM50625802(CHEMBL5420350)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-AMC as substrate incubated for 60...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM50625803(CHEMBL5410522)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal his6-tagged human recombinant glutaminyl cyclase expressed in Escherichia coli using H-Gln-AMC as substrate incubated for 60...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM50519291(CHEMBL4462495 | US20240059675, Compound SEN177 | U...)
Affinity DataKi:  20nMAssay Description:Inhibition of human glutaminyl cyclase assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Shenzhen University Medical School

Curated by ChEMBL
LigandPNGBDBM308046(US9650362, 14 | (S)-1-(1H- benzo[d]imidazol-5-yl)-...)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant glutaminyl cyclase using glutaminyl-7-amido-4-methylcoumarin as substrate assessed as inhibition constant by micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed