Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50020554
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  100nMAssay Description:Induction of degradation of CAMKK2 in human VCaP cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  100nMAssay Description:Induction of degradation of CAMKK2 in human THP-1 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetElongin-C(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataKd:  130nMAssay Description:Binding affinity to N-terminal 6 his tagged VHL (54 to 213 residues)/truncated ElonginC (17 to 122 residues) /full length ElonginB (unknown origin) e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631200(CHEMBL5424004)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631199(CHEMBL5440885)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631198(CHEMBL5434028)
Affinity DataEC50:  4.50E+3nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631197(CHEMBL5416036)
Affinity DataEC50:  530nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  290nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631196(CHEMBL5412289)
Affinity DataEC50:  620nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631195(CHEMBL5394508)
Affinity DataEC50:  510nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631194(CHEMBL5395520)
Affinity DataEC50:  2.00E+3nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631193(CHEMBL5430196)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged degradation of CaMKK2 (unknown origin) expressed in HEK292T cells incubated for 24 hrs by luminescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataEC50:  200nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631189(CHEMBL5421767)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631188(CHEMBL5439578)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50296011(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631191(CHEMBL5431962)
Affinity DataIC50: 4nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631186(CHEMBL5426746)
Affinity DataIC50: 7nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 7nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631189(CHEMBL5421767)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataIC50: 9nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631190(CHEMBL5397685)
Affinity DataIC50: 11nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631191(CHEMBL5431962)
Affinity DataIC50: 12nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631188(CHEMBL5439578)
Affinity DataIC50: 12nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631186(CHEMBL5426746)
Affinity DataIC50: 26nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631189(CHEMBL5421767)
Affinity DataIC50: 47nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631190(CHEMBL5397685)
Affinity DataIC50: 50nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 54nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631191(CHEMBL5431962)
Affinity DataIC50: 77nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631187(CHEMBL5396413)
Affinity DataIC50: 79nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631190(CHEMBL5397685)
Affinity DataIC50: 80nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631192(CHEMBL5422255)
Affinity DataIC50: 94nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 120nMAssay Description:Inhibition of CaMKK1 (unknown origin) incubated for 20 mins in presence of kinase tracer 236 by TR-FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM92455(CHEMBL265470 | STO-609)
Affinity DataIC50: 120nMAssay Description:Inhibition of CaMKK2 (161 to 449 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) star cells incubated for 20 mins in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631186(CHEMBL5426746)
Affinity DataIC50: 170nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50631188(CHEMBL5439578)
Affinity DataIC50: 180nMAssay Description:Inhibition of CaMKK2 in LKB1 null human A-427 cells assessed as inhibition of AMPK phosphorylation preincubated for 4 hrs followed by calcium ionopho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed