Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with all data for entry = 50020551
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518423(US11124500, Example 17 | 6-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 2nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518443(US11124500, Example 34 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518442(US11124500, Example 33 | 4-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518418(US11124500, Example 12 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518443(US11124500, Example 34 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518418(US11124500, Example 12 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518417(US11124500, Example 11 | 6-[1-(2-Hydroxyethyl)pyra...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518443(US11124500, Example 34 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518442(US11124500, Example 33 | 4-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518418(US11124500, Example 12 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518414(US11124500, Example 8 | 2-[(2S)-2-Methylazetidin-1...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518442(US11124500, Example 33 | 4-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 6nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518426(US11124500, Example 20 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518429(US11124500, Example 23 | 6-[1-[2-[(3S,4S)-3,4- Dih...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518414(US11124500, Example 8 | 2-[(2S)-2-Methylazetidin-1...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518419(US11124500, Example 13 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518417(US11124500, Example 11 | 6-[1-(2-Hydroxyethyl)pyra...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518426(US11124500, Example 20 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM319585(US10174007, Example 4 | US10787438, Example 4 | US...)
Affinity DataIC50: 13nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518433(US11124500, Example 25 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50631167(CHEMBL5397861)
Affinity DataIC50: 15nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518423(US11124500, Example 17 | 6-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518423(US11124500, Example 17 | 6-[1-(Azetidin-3-yl)pyraz...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518419(US11124500, Example 13 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518424(US11124500, Example 18 | 6-[1-[1-(2-Aminoacetyl)-4...)
Affinity DataIC50: 16nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518433(US11124500, Example 25 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518406(US11124500, Example 1 | 2-[4-[2-[(2S)-2-Methylazet...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518414(US11124500, Example 8 | 2-[(2S)-2-Methylazetidin-1...)
Affinity DataIC50: 20nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518416(US11124500, Example 10 | 6-[1-[2-(Dimethylamino)et...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518406(US11124500, Example 1 | 2-[4-[2-[(2S)-2-Methylazet...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518419(US11124500, Example 13 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 26nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518416(US11124500, Example 10 | 6-[1-[2-(Dimethylamino)et...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518425(US11124500, Example 19 | 6-[1-(1-Acetyl-4-piperidy...)
Affinity DataIC50: 29nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518434(US11124500, Example 26 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 33nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518433(US11124500, Example 25 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 34nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518428(US11124500, Example 22 | 6-[1-[2-[(3R,4R)-3,4- Dih...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518426(US11124500, Example 20 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518434(US11124500, Example 26 | 2-[(2S)-2-Methylazetidin-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518411(US11124500, Example 5 | 2-[4-[5-Cyano-6-[(2S)-2-me...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518427(US11124500, Example 21 | 2-[4-[5-Cyano-6-[(2S)-2- ...)
Affinity DataIC50: 39nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518409(US11124500, Example 3 | [(2R)-1-[4-[1-(Azetidin-3-...)
Affinity DataIC50: 40nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518406(US11124500, Example 1 | 2-[4-[2-[(2S)-2-Methylazet...)
Affinity DataIC50: 41nMAssay Description:Inhibition of KHK in human HepG2 cells incubated for 3 hrs by Rapidfire MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518429(US11124500, Example 23 | 6-[1-[2-[(3S,4S)-3,4- Dih...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518409(US11124500, Example 3 | [(2R)-1-[4-[1-(Azetidin-3-...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human KHK-C preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM518409(US11124500, Example 3 | [(2R)-1-[4-[1-(Azetidin-3-...)
Affinity DataIC50: 45nMAssay Description:Inhibition of human KHK-A preincubated for 15 mins followed by substrate addition and measured after 20 mins in presence of ATP by Rapidfire MS analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
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