Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50020547
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631111(CHEMBL5437537)
Affinity DataEC50:  8.17E+3nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631112(CHEMBL5398491)
Affinity DataEC50:  82nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631113(CHEMBL5413930)
Affinity DataEC50:  10nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631114(CHEMBL5435124)
Affinity DataEC50:  2.70E+3nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631115(CHEMBL5426069)
Affinity DataEC50: >2.30E+4nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetRyanodine receptor 2(Homo sapiens)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631116(CHEMBL5409619)
Affinity DataEC50:  19nMAssay Description:Modulator activity at wild type RyR2 (unknown origin) expressed in HEK293T co-expressed with R-CEPIA1er assessed as decrease in RyR2-mediated calcium...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631117(Arm-210 | Rycal dmd | S48168 | ARM210 | S-48168 | ...)
Affinity DataEC50:  3.43E+4nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631111(CHEMBL5437537)
Affinity DataEC50:  2.20E+3nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631112(CHEMBL5398491)
Affinity DataEC50:  8.60E+3nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631113(CHEMBL5413930)
Affinity DataEC50:  7.60E+3nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631118(CHEMBL5409315)
Affinity DataEC50: >1.00E+6nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631114(CHEMBL5435124)
Affinity DataEC50:  9.20E+3nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631115(CHEMBL5426069)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631116(CHEMBL5409619)
Affinity DataEC50:  1.09E+4nMAssay Description:Activation of SERCA2a in mouse HL-1 cells assessed as increase in caffeine-induced calcium release incubated for 2 hrs by FLIPR Calcium 6 dye based c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Human)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631114(CHEMBL5435124)
Affinity DataEC50:  16nMAssay Description:Activation of SERCA2a in human HEK293T cells endoplasmic reticulum assessed as increase in calcium release measured for 10 mins in presence of ATP by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 2(Mouse)
Max Planck Institute for Multidisciplinary Sciences

Curated by ChEMBL
LigandPNGBDBM50631114(CHEMBL5435124)
Affinity DataEC50:  383nMAssay Description:Activation of SERCA2a in C57BL/6N mouse sarcoplasmic reticulum assessed as increase in calcium release measured for 10 mins in presence of ATP by NAD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed