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Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50019451
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619381(CHEMBL5403228)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619385(CHEMBL5395179)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor measured after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619383(CHEMBL5435378)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor measured after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619380(CHEMBL5422403)
Affinity DataEC50:  100nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor measured after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM21393(cid_1220 | CHEMBL56 | 7-(dipropylamino)-5,6,7,8-te...)
Affinity DataEC50:  14nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619384(CHEMBL5409943)
Affinity DataEC50:  600nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619380(CHEMBL5422403)
Affinity DataEC50:  6nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619382(CHEMBL5437394)
Affinity DataEC50:  700nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619383(CHEMBL5435378)
Affinity DataEC50:  100nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619385(CHEMBL5395179)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at Sprague-Dawley rat hippocampal membrane 5-HT1A receptor assessed as stimulation of [35S]GTPgammaS binding measured after 90 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50241107(CHEMBL219916 | 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619383(CHEMBL5435378)
Affinity DataIC50: 8.40E+3nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619380(CHEMBL5422403)
Affinity DataIC50: 1.16E+4nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619385(CHEMBL5395179)
Affinity DataIC50: 1.83E+4nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619381(CHEMBL5403228)
Affinity DataIC50: 2.26E+4nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619384(CHEMBL5409943)
Affinity DataIC50: 2.48E+4nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619382(CHEMBL5437394)
Affinity DataIC50: 5.03E+4nMAssay Description:Antagonist activity at Sprague-Dawley rat striatum membrane D2 receptor assessed as inhibition of dopamine stimulated [35S]GTPgammaS binding measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50017696(N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamin...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-{4-[(4-fluorophenyl)carbonyl]piperidin-1-yl}e...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619381(CHEMBL5403228)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619385(CHEMBL5395179)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619383(CHEMBL5435378)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619384(CHEMBL5409943)
Affinity DataKi:  80nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619383(CHEMBL5435378)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619380(CHEMBL5422403)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619385(CHEMBL5395179)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619380(CHEMBL5422403)
Affinity DataKi:  300nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetHistamine H1 receptor(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619382(CHEMBL5437394)
Affinity DataKi:  600nMAssay Description:Displacement of [3H]pyrilamine from Sprague-Dawley rat H1 receptor assessed as inhibition constant measured after 30 mins by competitive binding assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619382(CHEMBL5437394)
Affinity DataKi:  4.70E+3nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50619384(CHEMBL5409943)
Affinity DataKi:  2.53E+4nMAssay Description:Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed