Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50020477
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630285(CHEMBL5425575)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 11nMAssay Description:Inhibition of DGAT2 in human hepatocytes using 14C-glycerol as a substrate pre incubated for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM276750(US10071992, Example 3.4 | (S)-2-(5-((3-ethoxypyrid...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 17nMAssay Description:Inhibition of rat DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Trilux...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504482(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 23nMAssay Description:Inhibition of DGAT2 in human hepatocytes using 14C-glycerol as a substrate pre incubated for 45 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504494(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[...)
Affinity DataIC50: 42nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504492(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504505(US11065249, Example 19 | First-eluting enantiomer ...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630284(CHEMBL5394885)
Affinity DataIC50: 200nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630288(CHEMBL5408882)
Affinity DataIC50: 410nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM576482(US11471458, Example 16 | US20230405002, Example 16)
Affinity DataIC50: 480nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630289(CHEMBL5415392)
Affinity DataIC50: 500nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630286(CHEMBL5399121)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM642342(2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}-N-[...)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50630287(CHEMBL5437956)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human DGAT2 using 14C decanoyl-CoA as a substrate pre incubated for 2 hrs followed by substrate addition measured after 40 mins by Tril...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of DGAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MGAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MGAT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM504484(2-{5-[(3-Ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of MGAT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed