Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50020472
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50:  77nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50:  134nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50:  1.97E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630224(CHEMBL5408759)
Affinity DataEC50:  3.63E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataEC50:  6.80E+3nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630226(CHEMBL5394367)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630227(CHEMBL5403272)
Affinity DataEC50:  1.77E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633261(US20190276450, Example 1)
Affinity DataEC50:  5.50E+3nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK1 in human TF-1 cells assessed as reduction in IL-6 induced STAT3 phosphorylation at Tyr705 residue preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  195nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50: >1.90E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK2 in human UT7 cells assessed as reduction in erythropoietin induced STAT5 phosphorylation preincubated for 30 mins followed by eryt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50: >1.90E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633301(US20190276450, Example 7)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM633324(US20190276450, Example 14.4)
Affinity DataEC50: >2.00E+4nMAssay Description:Inhibition of JAK3 in human T-blast cells assessed as reduction in IL-2 induced STAT5 phosphorylation preincubated for 30 mins followed by IL-2 stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  160nMAssay Description:Inhibition of TYK2 in human whole blood assessed as decrease in STAT4 phosphorylation preincubated for 30 mins followed by human IL-23 stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633291(US20190276450, Example 4)
Affinity DataEC50:  1.40E+3nMAssay Description:Inhibition of TYK2 in C57/B6 mouse whole blood assessed as decrease in STAT4 phosphorylation preincubated for 30 mins followed by mouse IL-12p70 stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633360(US20190276450, Example 25)
Affinity DataEC50:  30nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataEC50:  120nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630224(CHEMBL5408759)
Affinity DataEC50:  540nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataEC50:  20nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630226(CHEMBL5394367)
Affinity DataEC50:  24nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630227(CHEMBL5403272)
Affinity DataEC50:  93nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataEC50:  194nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633329(US20190276450, Example 16)
Affinity DataEC50:  310nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633331(US20190276450, Example 16a)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633261(US20190276450, Example 1)
Affinity DataEC50:  60nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633286(US20190276450, Example 2a.3)
Affinity DataEC50:  127nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633300(US20190276450, Example 6.3)
Affinity DataEC50:  350nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633280(US20190276450, Example 2.8)
Affinity DataEC50:  40nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633295(US20190276450, Example 5)
Affinity DataEC50:  110nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633349(US20190276450, Example 22.2)
Affinity DataEC50:  90nMAssay Description:Inhibition of TYK2 in human T-blast cells assessed as IL-12 induced STAT4 phosphorylation at Tyr694 residue preincubated for 30 mins followed by IL-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630226(CHEMBL5394367)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633261(US20190276450, Example 1)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630227(CHEMBL5403272)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630225(CHEMBL5414765)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633329(US20190276450, Example 16)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630228(CHEMBL5418687)
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM633331(US20190276450, Example 16a)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630224(CHEMBL5408759)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant human N-terminal His-tagged TYK2 JH2 domain (577 to 870 residues) expressed in Sf9 cells using N-(2-(2-(2-((3-(5-acetamido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50630223(CHEMBL5396134)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed