Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50020817
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633758(CHEMBL5408365)
Affinity DataEC50:  1.42E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633759(CHEMBL5423312)
Affinity DataEC50:  9.01E+3nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633760(CHEMBL5407030)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633761(CHEMBL5409133)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633762(CHEMBL5421240)
Affinity DataEC50:  1.53E+3nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633763(CHEMBL5437657)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633764(CHEMBL5415819)
Affinity DataEC50:  5.45E+3nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633765(CHEMBL5412370)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633766(CHEMBL5428535)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633767(CHEMBL5412803)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633768(CHEMBL5408826)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633769(CHEMBL5401359)
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50633770(CHEMBL5405559)
Affinity DataEC50:  4.37E+3nMAssay Description:Agonist activity at SOS1 in human HeLa cells expressing wild type KRAS assessed as increase in p-ERK level incubated for 30 mins by Western blot anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of GST-tagged human KRAS G12C mutant expressed in Escherichia coli/His10-tagged human SOS1 catalytic domain expressed in Escherichia coli ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed