Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50020311
TargetHIV-1 protease(Human immunodeficiency virus)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50628742(CHEMBL5422598)
Affinity DataEC50:  4.80nMAssay Description:Inhibition of HIV proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetKetohexokinase(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50628740(CHEMBL5402865)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of KHK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM577554(WO2022263472, Example 4 | 2-[[1-[(1 R)-2,2-Difluor...)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50244440(CHEMBL4065122)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50254270(CHEMBL4080943)
Affinity DataIC50: 3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50572101(CHEMBL4861069)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of KIT V654A mutant (unknown origin) by FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM472782(US10829493, Example 8)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of KIT D816V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM472782(US10829493, Example 8)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PDGFRalpha D842V mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50593284(CHEMBL5177770)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminal Avi-tagged human Cbl-b (40 to 426 residues) expressed in Escherichia coli by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM212271(US9504684, Ex.-2 | 6-(6-aminopyrazin-2-yl)-N-(4-(4...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50628741(CHEMBL5414165)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM185149(Crenolanib | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy...)
Affinity DataIC50: 10nMAssay Description:Inhibition of wildtype human PDGFRalpha transfected with CHO cells by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50597032(CHEMBL5196215)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50580006(CHEMBL5090730 | US20230357269, Example 14)
Affinity DataIC50: 10nMAssay Description:Inhibition of LRRK2 in human PBMCs assessed as reduction in Ser95 phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
Imperial College London

Curated by ChEMBL
LigandPNGBDBM50015448(CHEMBL3265032)
Affinity DataIC50: 17nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed