Compile Data Set for Download or QSAR
Report error Found 93 Enz. Inhib. hit(s) with all data for entry = 50020305
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413625(2-{4-[5-Chloro-2-(1H-tetrazol-1-yl)phenyl]-5-metho...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628684(CHEMBL5432831)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628681(CHEMBL5440284)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413847(US10421742, Example 240 | 4-{[(2S)-2-{4-[5-Chloro-...)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628683(CHEMBL5400795)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413770(US10421742, Example 163 | N-(Quinoxalin-6-yl)-(2S)...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413858(US10421742, Example 251 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 0.740nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413775(US10421742, Example 168 | (2S)-2-{4-[5-Chloro-2-(4...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413840(US10421742, Example 233 | (2S)-2-[4-{5-Chloro-2-[4...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628696(CHEMBL5395642)
Affinity DataIC50: 0.810nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM528194(US11180471, Example 172 | 2-{4-[5-Chloro-2-(1H-tet...)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413772(US10421742, Example 165 | (2S)-2-[4-{5-Chloro-2-[4...)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413844(US10421742, Example 237 | (2S)-2-[4-{5-Chloro-2-[4...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413849(US10421742, Example 242 | 4-{[(2S)-2-{4-[5-Chloro-...)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413842(US10421742, Example 235 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 0.920nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413706(2-{4-[5-Chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)p...)
Affinity DataIC50: 0.960nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413848(US10421742, Example 241 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413819(US10421742, Example 212 | (2S)-2-{4-[5-Chloro-2-(4...)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413842(US10421742, Example 235 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of FXIa (unknown origin) measured after 40 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628677(CHEMBL5404596)
Affinity DataIC50: 1nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628679(CHEMBL5437779)
Affinity DataIC50: 1nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413839(US10421742, Example 232 | 2-[4-{5-Chloro-2-[4-(tri...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413842(US10421742, Example 235 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human plasma Kallikrein using H-Pro-Phe-Arg-AMC as substrate measured after 40 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628678(CHEMBL5427891)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628680(CHEMBL5419156)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413774(US10421742, Example 167 | US10421742, Example 225 ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413768(US10421742, Example 161 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628682(CHEMBL5400667)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628676(CHEMBL5434010)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628697(CHEMBL5441044)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413809(US10421742, Example 202 | 4-{[(2S)-2-{4-[5-Chloro-...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413629(2-{4-[5-Chloro-2-(1H-imidazol-1-yl)phenyl]-5-metho...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628674(CHEMBL5428779)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413771(US10421742, Example 164 | 2-[4-{5-Chloro-2-[4-(dif...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628673(CHEMBL5398062)
Affinity DataIC50: 2nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM246258(US9434690, 164 | US10183932, Example 164 | US98221...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413649(2-{4-[5-Chloro-2-(1,2-oxazol-3-yl)phenyl]-5-methox...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628691(CHEMBL5439131)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413613(2-{4-[5-Chloro-2-(1,3-oxazol-5-yl)phenyl]-5-methox...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413789(US10421742, Example 182 | 4-({(2S)-2-[4-{5-Chloro-...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413658(2-{4-[5-Chloro-2-(4-chloro-1H-imidazol-1-yl)phenyl...)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628689(CHEMBL5412953)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628669(CHEMBL5407743)
Affinity DataIC50: 4nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413636(2-{4-[5-Chloro-2-(1,3,4-oxadiazol-2-yl)phenyl]-5-m...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413783(US10421742, Example 176 | 2-[4-{5-Chloro-2-[5-(dif...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628693(CHEMBL5406534)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413616(2-{4-[5-Chloro-2-(4,5-dihydro-1,2-oxazol-3-yl)phen...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628675(CHEMBL5416199)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCoagulation factor XI(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM413665(2-{4-[5-Chloro-2-(4H-1,2,4-triazol-4-yl)phenyl]-5-...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human FXIa using Boc-Glu(OBzl)-Ala-Arg-AMC as substrate measured for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50628681(CHEMBL5440284)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human plasma Kallikrein using H-Pro-Phe-Arg-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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