Compile Data Set for Download or QSAR
Report error Found 50 Enz. Inhib. hit(s) with all data for entry = 50020295
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataEC50:  700nMAssay Description:Inhibition of NOX5 (unknown origin) transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataEC50:  500nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628601(CHEMBL5435186)
Affinity DataIC50: 19nMAssay Description:Inhibition of NOX1 (unknown origin) expressed in HT 29 cells assessed as inhibition of PMA-induced hydrogen peroxide production pre-incubated for 15 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NOX5 expressed in HEK293 cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pretreated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human NOX4 expressed in HEK293T cells assessed as inhibition of teracycline-induced hydrogen peroxide production pretreated for 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 100nMAssay Description:Inhibition of human NOX2 transfected in PLB-985 cells assessed as PMA-induced hydrogen peroxide pre-incubated for 10 and measured after 15 mins by Am...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 100nMAssay Description:Inhibition of NOX2 in human PLB-985 cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628597(CHEMBL5413611)
Affinity DataIC50: 149nMAssay Description:Inhibition of NOX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 240nMAssay Description:Inhibition of human NOX1 expressed in CHO cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42323(SMR000033635 | MLS000047624 | cid_81131 | 1-(10H-p...)
Affinity DataIC50: 250nMAssay Description:Inhibition of human NOX1 transfected in HEK293T cells incubated for 16 hrs and measured after 30 mins by luminol-chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 300nMAssay Description:Inhibition of human NOX2 expressed in HEK cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pre-incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 410nMAssay Description:Inhibition of human NOX1 expressed in CHO cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 500nMAssay Description:Inhibition of human NOX1 expressed in HEK cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pre-incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 500nMAssay Description:Inhibition of human NOX1 transfected in CHO cells assessed as PMA-induced hydrogen peroxide pre-incubated for 10 and measured after 15 mins by Amplex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 570nMAssay Description:Inhibition of NOX5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 590nMAssay Description:Inhibition of NOX2 in human PLB-985 cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 680nMAssay Description:Inhibition of NOX4 ( unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDual oxidase 1(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 700nMAssay Description:Inhibition of human DUOX1 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production preincubated for 15 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628600(CHEMBL5436229)
Affinity DataIC50: 740nMAssay Description:Inhibition of NOX2 (unknown origin) transfected in HEK293 cells assessed as inhibition of hydrogen peroxide production pe-incubated for 15 mins and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628595(CHEMBL5416189)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NOX2 (unknown origin) expressed in HEK293T cells assessed as inhibition of PMA-induced superoxide production preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50000788([17-(2,3-3H-2-propenyl)]-4, 5a -epoxy-3,14-dihydro...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of human NOX2 expressed in HEK293T cells assessed as inhibition of LPS-induced superoxide production pre-incubated for 45 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628592(CHEMBL5419783)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NOX1 (unknown origin) expressed in HEK293 cells assessed as ROS production incubated for 45 mins and measured after 5 mins by chemilumi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human NOX5 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628598(CHEMBL5424942)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50497042(CHEMBL3249799)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of human NOX2 expressed in HEK293T cells assessed as inhibition of LPS-induced superoxide production pre-incubated for 45 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDual oxidase 2(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human DUOX2 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production preincubated for 15 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of human NOX4 expressed in HEK293T cells assessed as inhibition of teracycline-induced hydrogen peroxide production pretreated for 18 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42323(SMR000033635 | MLS000047624 | cid_81131 | 1-(10H-p...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NOX2 transfected in HEK293T cells incubated for 16 hrs ans measured after 30 mins by luminol-chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42323(SMR000033635 | MLS000047624 | cid_81131 | 1-(10H-p...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NOX3 transfected in HEK293T cells incubated for 16 hrs ans measured after 30 mins by luminol-chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM42323(SMR000033635 | MLS000047624 | cid_81131 | 1-(10H-p...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NOX4 transfected in HEK293T cells incubated for 16 hrs ans measured after 30 mins by luminol-chemiluminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of human NOX5 expressed in HEK293 cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pretreated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of NOX3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628599(CHEMBL5399030)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human NOX4 in T-REx-293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human NOX4 transfected in HEK293-T-REx cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of NOX1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NOX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628596(CHEMBL5422818)
Affinity DataIC50: 1.67E+4nMAssay Description:Inhibition of human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence based micropl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628599(CHEMBL5399030)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human NOX2 in PBMC cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 3(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628589(CHEMBL4210329)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human NOX3 transfected in HEK293-T-REx cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628597(CHEMBL5413611)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of human NOX2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628593(CHEMBL5431951)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of human NOX2 transfected in HEK293T cells assessed as inhibition of PMA-induced superoxide production preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628594(CHEMBL5414453)
Affinity DataIC50: 9.90E+4nMAssay Description:Inhibition of human NOX2 transfected in HEK293T cells assessed as inhibition of PMA-induced superoxide production preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628597(CHEMBL5413611)
Affinity DataKi:  54nMAssay Description:Binding affinity to NOX2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  110nMAssay Description:Binding affinity to human NOX4 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  140nMAssay Description:Binding affinity to human NOX1 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  410nMAssay Description:Binding affinity to human NOX5 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628590(ISUZINAXIB)
Affinity DataKi:  570nMAssay Description:Binding affinity to human NOX2 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628590(ISUZINAXIB)
Affinity DataKi:  630nMAssay Description:Binding affinity to human NOX4 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628590(ISUZINAXIB)
Affinity DataKi:  1.08E+3nMAssay Description:Binding affinity to human NOX1 assessed as reduction in ROS production using lucigenin as substrate in presence of NADPH by chemiluminescence base as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetCytochrome b-245 heavy chain(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  1.75E+3nMAssay Description:Binding affinity to human NOX2 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed