Compile Data Set for Download or QSAR
Report error Found 89 Enz. Inhib. hit(s) with all data for entry = 50020293
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataEC50:  2.5nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50628588(CHEMBL5434074)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of DPP-4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228403(8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-m...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant DPP-4 in Caco-2 cells using GP-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM205995(US9255098, Ex. 1 | US9255098, Ex. 4)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of DPP-4 (unknown origin) measured after 5 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50003020(MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin ...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11694(Cyclohexylglycine-(2S)-cyanopyrolidine 3 | (2S)-1-...)
Affinity DataIC50: 2nMAssay Description:Inhibition of DPP-4 (unknown origin) using H-Gly-Pro-AMC as substrate measured after 20 mins by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50628584(CHEMBL5408495)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50628585(CHEMBL5418259)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50628587(CHEMBL5430453)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human recombinant DPP-4 using H-Gly-Pro-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of DPP-4 in human Caco-2 cells using H-Ala-Pro-pNA as substrate preincubated for 30 mins followed by substrate addition measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM12466(1-[(1-Adamantylamino)acetyl]-2-pyrrolidinecarbonit...)
Affinity DataIC50: 4nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human recombinant DPP-4 in Caco-2 cells using GP-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 7nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM664705(methyl (R)-7-(3-amino-4-(2,4,5- trifluorophenyl)bu...)
Affinity DataIC50: 12nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50151832(2-{(R)-4-[3-Amino-4-((R)-2-fluoro-phenyl)-butyryl]...)
Affinity DataIC50: 14nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant DPP-4 in Caco-2 cells using GP-AMC as substrate by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50151840((R)-3-Amino-1-((R)-2-benzyl-piperazin-1-yl)-4-(2,4...)
Affinity DataIC50: 19nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11113(NVP-DPP728 | cyanopyrrolidine derivative 2 | CHEMB...)
Affinity DataIC50: 22nMAssay Description:Inhibition of DPP-4 in human Epithelial cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Mouse)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 34nMAssay Description:Inhibition of human recombinant DPP-4 (1 to 530 residues) using Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataIC50: 62nMAssay Description:Inhibition of human recombinant DPP-4 expressed in human Caco-2 cells using H-Ala-Pro-7-amido-4-trifluoromethylcoumarin as substrate measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM15564(CHEMBL363319 | (3R)-3-amino-1-(1,3-thiazolidin-3-y...)
Affinity DataIC50: 119nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50151825(2-[4-((R)-3-Amino-4-phenyl-butyryl)-3-benzyl-piper...)
Affinity DataIC50: 134nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProlyl endopeptidase FAP(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of FAPalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11557((2S)-1-[(3R)-3-amino-4-phenylbutanoyl]-N-({5-chlor...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50628583(CHEMBL1235760)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of DPP-4 (unknown origin) using Gly-Pro-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50151805(CHEMBL184262 (24) | CHEMBL184262 | (R)-3-Amino-4-p...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50228408(7-benzyl-3-methyl-8-(piperazin-1-yl)-1H-purine-2,6...)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of DPP-4 (unknown origin) using Gly-Pro-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human recombinant DPP-4 using Gly-Pro-7-amido-4-methylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetProlyl endopeptidase(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50225074(CHEMBL385517 | BMS-477118 | (1S,6S)-2-(2-adamantan...)
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of PEP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11560(CHEMBL37980 | 5-(aminomethyl)-6-(2H-1,3-benzodioxo...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM50151823(2-[4-((S)-2-Amino-3-phenyl-propyl)-3-benzyl-pipera...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of DPP-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
Sichuan Normal University

Curated by ChEMBL
LigandPNGBDBM11162(Triazolopiperazine Analogue 1 | (3R)-3-amino-1-[3-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human recombinant DPP-4 using Gly-Pro-7-amido-4-methylcoumarin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
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