Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50019323
TargetProtein cereblon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618118(CHEMBL5413040)
Affinity DataIC50: 2.60E+3nMAssay Description:Binding affinity to GST-tagged wild type human CRBN incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50070114(CHEMBL468 | 2-(2,6-dioxopiperidin-3-yl)isoindoline...)
Affinity DataIC50: 2.90E+3nMAssay Description:Binding affinity to GST-tagged wild type human CRBN incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetProtein cereblon(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM65454(Lenalidomide | US9694015, 6.1 | 191732-72-6 | Revl...)
Affinity DataIC50: 3.60E+3nMAssay Description:Binding affinity to GST-tagged wild type human CRBN incubated for 3 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 5 mins in presence substrate followed by NADPH addition and measured after 10 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition and measured after 10 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50618119(CHEMBL5438736)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG in human HEK293 cells incubated for 5 mins by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed